血清胱抑素C（CysC）联合尿微量清蛋白（mALB）对妊娠早期肾损害的诊断价值

Diagnostic value of serum cystatin C （CysC） and urinary albumin （mALB） for renal damage in early pregnancy

目的：探讨分析临床上对妊娠高血压患者采用血清胱抑素C联合尿微量清蛋白检测疾病早期肾损害的实际效果。方法：随机选取120例2013年1月-2016年1月在我院接受治疗的妊娠高血压患者作为研究对象，同时随机选取120例同一时期在我院接受分娩的正常孕妇作为对照组，比较分析妊娠高血压患者和正常孕妇血清胱抑素C和尿微量清蛋白，单项检测及两项同时检测妊娠高血压疾病患者早期肾损害的敏感性和特异性。结果：在血清中胱抑素C含量和尿中微量清蛋白含量方面，研究组的孕妇均高于对照组的孕妇[（2.21±0.79），（0.69±0.12）],[（40.54±18.96），（20.17±15.41）]，两者比较差异显著，具有统计学意义（P〈0.05）；血清中胱抑素C和尿中微量清蛋白含量独立及联合检测对妊娠高血压患者早期肾损害的特异性和敏感性比较，结果显示联合检测的特异性和敏感性均明显高于胱抑素C或者微量清蛋白单独检测（97.1%，88.8%，86.6%），（95.8%，83.5%，82.7%），差异显著，差别具有统计学意义（P〈0.05）。结论：临床上对妊娠高血压患者采用血清胱抑素C联合尿微量清蛋白检测疾病早期肾损害，敏感性和特异性均较高，有利于在疾病的早期发现患者的肾损害。

Objective： To investigate the clinical value of combined detection of serum cystatin C and urine albumin in early diagnosis of renal damage in patients with hypertension disease during pregnancy. Methods： 120 patients for treatment of pregnancy induced hypertension were randomly selected as the research object during January 2013 to January 2016 in our hospital, and 120 cases of normal pregnant women for delivery during the same period in our hospital were randomly selected as control group, the levels of urine albumin and serum cystatin C, and the sensitivity and specificity of single detection and combined detection in diagnosis of early renal damage were analyzed. Results： The content of serum cystatin C and urine albumin in study group were higher than the control group [（2.21±0.79）, （0.69±0.12）] , [（40.54±18.96）, （20.17±15.41）] , the difference were statistically significant （ P〈0.05） . Also the results showed that the sensitivity and specificity of combined detection were significantly higher than that of single detection （ 97.1%, 88.8%, 86.6%） , （ 95.8%, 83.5%, 82.7%） with statistically significant difference （ P〈0.05） . Conclusion： Combined detection of serum cystatin C and urinary albumin has higher sensitivity and specificity for the discovery of early renal damage in patients with hypertension disease during pregnancy.