阿托伐他汀与血管钙化的研究

Study on atorvastatin and vascular calcification

血管钙化是心血管疾病如动脉粥样硬化、肾病、收缩性高血压、糖尿病等共同的病生理基础,主要是血管壁钙盐异常沉积,与血管粥样硬化及血管顺应性降低密切相关。对血管钙化机制和治疗方法研究对临床会有极大的帮助。而近年来大量研究证明,他汀类药物不仅有降脂作用,具有抑制血管平滑肌成骨样分化、抗炎抗氧化、凋亡等机制,可能对防御或治疗血管钙化也有一定的影响,作者选具有代表性的他汀类药物—阿托伐他汀,对血管钙化影响的研究进展做综述。

Vascular calcification is the common physiological basis of cardiovascular diseases such as atherosclerosis,kidney disease,systolic hypertension,diabetes and other,which is mainly abnormal calcium salt deposition in the blood vessel walls,and it is closely related to vascular atherosclerosis and decreased vascular compliance. Research on vascular calcification mechanism and treatment method has great help on clinical treatment. In recent years,a large number of studies have shown that statins not only have lipid- lowering effect,with the mechanism of inhibiting osteogenic differentiation of vascular smooth muscle,anti-inflammatory,antioxidants and anti-apoptosis,but also have a certain influence on the prevention or treatment of vascular calcification. This article reviews the research progress of effect on vascular calcification from a representative sample of statins-atorvastatin.