摘要
单核苷酸多态性(single nucleotide polymorphism,SNP)作为第3代遗传标记,有助于解释不同群体和个体对肿瘤的易感性以及对治疗预后的敏感性差异。除了环境等外在综合致癌因素外,肝癌的发生和发展很大程度上与个体间基因型的遗传多态性密切相关。全文综述了SNP与肝癌易感性、治疗及预后之间的关系。
Single nucleotide polymorphism（SNP） is the third generation of genetic maker,which might be associated with tumor susceptibility and prognosis. The occurrence and development of HCC is not only related to environmental carcinogens,but also closely related to genetic polymorphism of individual. This paper reviews the relationship between the SNP and the susceptibility to HCC,treatment and prognosis.
出处
《中国肿瘤》
CAS
CSCD
2017年第3期196-202,共7页
China Cancer
基金
国家自然科学基金资助项目(81260320)
关键词
肝癌
单核苷酸多态性
遗传易感性
治疗
预后
hepatocellular carcinoma
single nucleotide polymorphism
hereditary susceptibility
treatment
prognosis
