丹参酮改善脓毒症肠屏障功能的研究进展

Review on Tanshinone Improving Intestinal Barrier Dysfunction in Sepsis

[目的]为进一步研究丹参酮在脓毒症肠屏障功能障碍中的作用提供参考。[方法]主要查阅近10年国内外有关丹参酮各种药理作用的研究,以及丹参酮在脓毒症特别是对肠屏障功能障碍的影响。[结果]丹参酮在脓毒症、心脑血管、抗肿瘤等领域的研究较多,其对脓毒症肠屏障功能方面的具体机制研究正在逐步深入之中,本文通过丹参酮抑菌抗炎、抗氧化、抗血小板凝集、改善微循环、调节免疫等功能的论述,阐述了丹参酮改善脓毒症肠屏障功能的可能机制。[结论]丹参酮可以改善脓毒症病理生理过程中,由于组织器官缺氧缺血和全身强烈炎症反应等因素导致肠屏障功能受损,但对于其作用具体机制,还需要进一步研究。

[Objective] To further study tanshinone role in intestinal barrier dysfunction in sepsis. [Methods] Mainly refer to nearly a decade at home and abroad on tanshinone pharmacological effects, and tanshinone in sepsis, especially the impact on the intestinal barrier dysfunction. [Results] Tanshinone in sepsis, and heart head blood-vessel, anti-tumor and so on in the field of study is more, but improving sepsis of intestinal barrier function in aspects of the study is less, but through tanshinone antibacterial anti-inflammatory, antioxidant, anti platelet aggregation, improve microcirculation, regulate immune function, this paper expounds tanshinone improving sepsis, possible mechanisms of intestinal barrier function. [Conclusion] Tanshinone can improve sepsis pathophysiological process, ischemia oxygen to the tissues and organs and whole body strong inflammatory reaction factors such as the cause of intestinal barrier function is impaired, but for its specific mechanism, further research is needed.