中性粒细胞胞外诱捕网在动脉粥样硬化中的研究进展

Research progress of neutrophil extracellular traps in atherosclerosis

动脉粥样硬化作为一种炎症反应性疾病,已成为心脑血管病领域的共识。而参与动脉粥样硬化炎症反应的细胞成分多种多样,包括单核-巨噬细胞、树突状细胞、T淋巴细胞及中性粒细胞等。中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是中性粒细胞活化时释放的网状物质,它具有抗炎、促炎、促凝等多种生物活性,并参与多种疾病的病理进程。研究发现:中性粒细胞可以在某些刺激因子作用下活化并释放出NETs,而NETs具有细胞毒性和血栓形成效应,并且能够与巨噬细胞产生交互作用,它作为将炎症和血栓形成联系起来的桥梁,在动脉粥样硬化的病理进程中发挥了重要作用。

It has become a consensus in the field of cardio-cerebrovascular disease that atherosclerosis is an inflammatory response disease, and inflammation cells involved in atherosclerotic are varied, including mononuclear-macrophages, dendritic cells, T lymphocytes and neutrophils, etc. Neutrophil extracellular traps （NETs） are mesh structure released by activated neutrophils. They have diverse biological activities, such as anti-inflammatory and proinflammatory effect, procoagulant activity. They also participate in pathological processes of many kinds of diseases. A number of studies found that neutrophils can be activated by some stimulating factor and release NETs. NETs have cytotoxic and pro-thrombotic effects, and the ability to interact with macrophages, they play an important role in atherosclerosis pathology as a link between inflammation and thrombosis.