超声对新生儿坏死性小肠结肠炎诊断价值的Meta分析

Diagnostic value of ultrasonography in necrotizing enterocolitis： a meta-analysis

目的系统评价超声对新生儿坏死性小肠结肠炎（NEC）的诊断价值。方法检索PubMed、EMbase、中国期刊全文数据库（CNKI）、维普数据库（VIP）、万方数据库、中国生物医学文献数据库（CBM）等，截止时间为2015年7月24日。按照诊断试验的纳入标准筛选关于超声对NEC诊断价值的诊断试验，采用诊断准确性研究质量评价（QUADAS）条目评价纳入研究的方法学质量，并采用Meta—Disc1．4软件进行Meta分析，绘制汇总受试者工作特征曲线（SROC曲线），计算曲线下面积。结果共纳入7项研究，包括485例病例。超声检查的敏感度为0．65（95％G，0．58～0．71），特异度为0．61（95％C10．55～0．67），SROC曲线下面积为0．726。结论超声并未显示较好的诊断价值，应将超声检查结果与临床表现相结合，有助于提高超声的诊断价值。

Objective To evaluate the diagnostic value of ultrasonography in neonatal necrotizing enteroeolitis （NEC） by Meta analysis. Methods PubMed, EMbase, CBM, CNKI, VIP and WanFang databases were retrieved to incorporate studies on the diagnostic value of ultrasound in NEC that met the inclusion criteria. The retrieval time limit was from establishment of the databases to July 24th, 2015. QUADAS was used to assess the quality of the literatures and Meta - Disc software （ Version 1.4） was used for Meta analysis. The SROC was drawn and the area under curve （ AUC ） of SROC was calculated. Results A total of 7 studies were included and 485 patients were involved. The sensitivity of the uhrasonography was O. 65 （95% CI O. 58 ~ O. 71 ） and the specificity was 0. 61 （95% CI O. 55 -0. 67）. The AUC of the SROC was 0. 726. Conclusion The uhrasonography showed no clear advantage for diagnosis of NEC. Combining with clinical manifestations would enhance the diagnostic ability of the ultrasound.