芩蒿滴鼻液对变应性鼻炎患者鼻分泌物中SP,TNF-α,Annexin1及VCAM-1含量的影响

Effect of Scutellaria Artemisia Nasal Drops on the SP, TNF-α, Annexin 1 and VCAM-1 Levels in Nasal secretions of Patients with Allergic Rhinitis

目的:探讨芩蒿滴鼻液对变应性鼻炎(AR)患者鼻分泌物中P物质(SP)、肿瘤坏死因子-α(TNF-α)、膜联蛋白1(Annexin1)、血管细胞黏附分子-1(VCAM-1)含量的影响。方法:选取我院耳鼻喉科收治的AR患者92例,随机分为对照组和实验组两组。对照组46例患者予曲安奈德鼻喷雾剂治疗,实验组46例患者加用芩蒿滴鼻液治疗。另选取健康体检患者46例。采用酶联免疫法测定各组患者鼻分泌物中TNF-α、Annexin1及VCAM-1的含量,采用放射免疫法测定SP的含量。结果:治疗后,两组鼻分泌物中SP、TNF-α及VCAM-1含量均较治疗前显著下降,Annexin1含量明显升高(P<0.05);与对照组比较,实验组鼻分泌物中SP、TNF-α及VCAM-1含量较低(P<0.05),Annexin1含量较高(P<0.05),实验组临床有效率(91.30%)较对照组(73.91%)显著升高,差异具有统计学意义(P<0.05)。结论:芩蒿滴鼻液能够明显降低AR患者鼻分泌物中SP、TNF-α、VCAM-1的含量,上调Annexin1的含量。

Objective： To investigate the effect of Scutellaria Artemisia Nasal Drops on the SP, TNF-α, Annexin1 and VCAM-1levels in the nasal secretions of patients with allergic rhinitis（AR）. Methods： 92 cases of patients with AR were selected and randomly divided into two groups. 46 cases in the control group were treated with triamcinolone acetonide spraying agent 20ug/kg, three times a day,sprayed into the nose, 46 cases in the experimental group were treated with Qin Hao nasal drops three times a day 2 weeks for a course of treatment, the TNF- alpha, Annexin1 and VCAM-1 in nasal secretions were determined by ELISA, SP content of inflammatory mediators was determined by radioimmunoassay. Results： After the treatment, the content of SP, TNF- alpha and VCAM-1 were decreased, the Annexin1 was increased. Compared with the control group, the SP, TNF- alpha and VCAM-1 levels as well as the clinical efficacy of experimental group were lower（P〈0.05）, the content of Annexin1 of experiment was higher（P〈0.05）. Conclusion： Qin Hao nasal drops could significantly reduce the SP, TNF- alpha, VCAM-1 content and upregulate the Annexin1 content in the nasal secretions of AR patients.