卵巢囊性颗粒细胞瘤的临床病理学特征、诊断及鉴别诊断

Clinicopathologic Features, Diagnosis and Differential Diagnosis of Ovarian Cystic Granulosa Cell Tumor

目的:探讨卵巢囊性颗粒细胞瘤的临床病理学特征、诊断和鉴别诊断要点。方法:复习1例卵巢囊性颗粒细胞瘤患者的临床资料、肿物的大体以及镜下病理组织学特征、免疫组化染色特征。结果:患者左侧单房囊性颗粒细胞瘤,大小为14.6 cm×18.9 cm×9.8 cm,囊壁厚薄不均一;镜下可见内壁由颗粒细胞组成,细胞层数不一,可见典型的Call-Exner小体;免疫组化染色可见α-inhibin,Vimentin,CD99均阳性。结论:卵巢囊性颗粒细胞瘤可依据镜下发现不典型增生的颗粒细胞、典型的Call-Exner小体和核沟等特征性的组织形态学作出诊断。

Objective： To explore the clinicopathologic features, diagnosis and differential diagnosis of ovarian cystic granulosa cell tumor. Methods： The clinical data of one case of ovarian cystic granulosa cell tumor were reviewed. And the gross and histological features of the tumor were studied. Results： The patient had a left-sided unilocular cystic granulosa cell tumor, with the size of 14.6 cm×18.9 cm×9.8 cm and uneven thickness of capsule wall. Under the microscope, the wall was consisted of granule cell, and the cell layer was visible. The typical Call-Exner bodies were also found under the microscope. Immunohistochemical staining results indicated that the alpha- inhibin, vimentin and CD99 were positive. Conclusion： The cystic granule cell tumor of the ovary could be diagnosed on the base of the histological characteristics like microscopic finding of atypical proliferation of granulosa cells, typical Call-Exner bodies and nuclear grooves.