奥扎格雷与银杏达莫对老年急性脑梗塞患者血清Cys-C和IL-6的影响

Effect of Ozagrel Combined with Ginkgo Leaf Extract and Dipyridamole Injection on Serum Cystatin C and IL-6 Level and in Elderly Patients with Acute Cerebral Infarction

目的:探讨奥扎格雷联合银杏达莫对老年急性脑梗塞患者血清胱抑素C(Cys-C),白介素-6(IL-6)及临床疗效的影响。方法:收集我院收治的150例急性脑梗塞患者,随机分为实验组和对照组,每组75例。两组患者入院后均给予抗血小板聚集,保护脑细胞等治疗措施,对照组患者给予银杏达莫注射液治疗;实验组患者在对照组的基础上给予奥扎格雷钠注射液治疗,治疗连续4周。观察并比较两组患血清Cys-C、IL-6、患者神经功能缺损评分(NIHSS)以及治疗的总有效率。结果:与治疗前相比,治疗后两组患者的血清Cys-C、IL-6以及NIHSS水平均下降,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的Cys-C、IL-6以及NIHSS水平较低,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的治疗总有效率较高,差异具有统计学意义(P<0.05)。结论:奥扎格雷联合银杏达莫能够降低老年急性脑梗塞患者血清Cys-C,IL-6水平,临床疗效较好,提高了治疗效果。

Objective： To investigate the effect of ozagrel combined with ginkgo leaf extract and dipyridamole on serum cystatin C（Cys-C） and interleukin 6（IL-6） level and the clinical efficacy in senile patients with acute cerebral infarction. Methods： 150 cases of elderly patients with acute cerebral infarction were randomly divided into experimental group and control group, 75 cases in each group.After admission, the patients in the two groups were given anti platelet aggregation, brain cells protection drugs, etc., and the control group were treated with ginkgo leaf extract and dipyridamole injection; and the patients in the experimental group were given ozagrel sodium injection on the basis of the control group, once a day, continuously treated for 4 weeks. The serum Cys-C and IL-6 level, neurological function deficit score（NIHSS） and the treatment of total efficiency was observed and compared between two groups. Results：compared with before treatment, the serum Cys-C, IL-6 and NIHSS levels were decreased after treatment in the two groups of patients,and the difference was statistically significant（P〈0.05）; compared with the control group, Cys-C, IL-6 and NIHSS level was lower in the experimental group, and the difference was statistically significant（P〈0.05）; compared with the control group, the total effective rate was higher in the experimental group with statistical significance（P〈0.05）. Conclusions： Ozagrel sodium combined with ginkgo leaf extract and dipyridamole can reduce serum cystatin C and IL-6 levels in the treatment of senile acute cerebral infarction, and can obtain good clinical curative effect.