氯吡格雷联合阿司匹林对冠心病心绞痛患者血清hs-CRP,TNF-α及IL-6水平的影响

Effects of Clopidogrel and Aspirin on the Serum Levels of hs-CRP,TNF-α and IL-6 in Patients with Coronary Heart Disease and Angina Pectoris

目的:探讨氯吡格雷与阿司匹林对冠心病心绞痛患者血清炎症因子水平的影响及其临床疗效。方法:选择2014年3月-2016年3月在我院确诊为冠心病心绞痛患者69例作为研究对象,根据治疗方法不同,将患者随机分成研究组(39例)和对照组(30例)。对照组患者采用阿司匹林治疗,研究组患者在此基础上联合使用氯吡格雷治疗。观察并比较两组患者治疗前后血清高敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及白细胞介素-6(interleukin-6,IL-6)水平的变化情况,以及临床疗效。结果:治疗前两组患者血清hs-CRP,IL-6及TNF-α水平比较,差异无统计学意义(P>0.05);治疗后两组患者血清hs-CRP,IL-6及TNF-α水平均低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。研究组患者临床总有效率(94.7%)高于对照组(88.9%),差异具有统计学意义(P<0.05)。结论:氯吡格雷联合阿司匹林治疗冠心病心绞痛的临床效果显著,能够降低患者血清hs-CRP,IL-6及TNF-α炎症因子水平,值得临床推广应用。

Objective： To investigate the effect of clopidogrel and aspirin on serum levels of inflammatory factors in patients with coronary heart disease and angina pectoris. Methods： 69 cases with angina pectoris and coronary heart disease who were diagnosed in our hospital from March 2014 to March 2016 were selected as the research objects, and according to the different treatment methods, the patients were randomly divided into the study group（39 cases） and the control group（30 cases）. The patients in the control group were treated with aspirin, and the patients in the study group were treated with clopidogrel on the basis of the control group. Then the serum levels of high sensitive C-reactive protein（hs-CRP）, tumor necrosis factor alpha（TNF-α） and leukocyte mediated IL-6（IL-6） in patients between the two groups before and after treatment were observed and compared. Results： Before treatment, there was no statistically significant difference about the serum levels of hs-CRP, IL-6 and TNF-α between the two groups（P〉0.05）; After treatment, the serum levels of hs-CRP, IL-6 and TNF-α in the two groups were lower than before, and the study group was lower than that of the control group, and the differences were statistically significant（P〈0.05）. The total effective rate in the study group was 94.7%, which was higher than 81.9% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion： The clinical effect of clopidogrel combined with aspirin in the treatment of angina pectoris and coronary heart disease is significant, which can reduce the serum levels of hs-CRP, IL-6 and TNF-α, and it is worthy of clinical application.