盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎的疗效观察

Efficacy of Glucosamine Hydrochloride Tablets combined with Sodium Hyaluronate in the treatment of Temporomandibular Joint Osteoarthritis

目的:研究盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎(TMJOA)的临床疗效,为临床治疗提供依据。方法:选取2012年11月到2015年11月我院收治的TMJOA患者60例,按照随机数字表法将患者分为研究组和对照组,每组30例,两组均给予玻璃酸钠关节腔注射,研究组在此基础上给予盐酸氨基葡萄糖片治疗,应用视觉模拟评分法(VAS)评价关节疼痛情况,比较两组临床疗效和不良反应,比较治疗前后两组最大张口度、张口VAS评分和张口偏斜。结果:研究组总有效率为83.33%(25/30),显著高于对照组的56.67%(17/30),比较差异具有统计学意义(P<0.05);治疗后两组张口VAS评分和张口偏斜显著降低,最大张口度显著增高,且研究组显著优于对照组,比较差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:盐酸氨基葡萄糖片联合玻璃酸钠治疗TMJOA具有较好的临床疗效,能有效改善患者关节功能。

Objective： To study the clinical efficacy of Glucosamine Hydrochloride Tablets combined with sodium hyaluronate in the treatment of Temporomandibular joint osteoarthritis（TMJOA）, to provide basis for clinical treatment. Methods： 60 cases of TMJOA who were treated in our hospital from November 2012 to November 2015 were selected, the patients were divided into study group and control group according to the random number table method, 30 cases in each group. Two groups were given sodium hyaluronate injection, the study group was given Glucosamine Hydrochloride Tablets treatment. Evaluated the joint pain with visual analogue scale（VAS）, the clinical efficacy and adverse reactions of the two groups were compared, the maximum mouth opening, mouth VAS score and mouth deviation of two groups were compared. Results： The total effective rate of the study group was 83.33%（25/30）, which was significantly higher than that of 56.67%（17/30） in the control group,the difference was statistically significant（P〈0.05）; The VAS score and the mouth opening deviation after treatment of the two groups were significantly decreased, maximum mouth opening increased significantly, and the study group was significantly better than the control group, the differences were statistically significant（P〈0.05）;There was no statistically significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion：Glucosamine Hydrochloride Tablets combined with sodium hyaluronate in the treatment of TMJOA has good clinical efficacy, which can effectively improve the patient＇s joint function.