绝经女性冠状动脉钙化积分与臂踝动脉脉搏波传导速度的相关性研究

Association between Coronary Artery Calcium Scoring and Brachial Ankle Pulse Wave Velocity in Post-menopause Women

目的:研究绝经女性中冠脉钙化积分(CACS)与臂踝动脉脉搏波传导速度(ba PWV)之间的相关性。方法:从1918名社区人群筛选出546名无冠心病病史并可以进行CACS检查的绝经女性为样本,对其进行标准化问卷调查、实验室指标检测、ba PWV及CACS测量。根据CACS将研究对象分为CACS=0组和CACS>0组,并根据ba PWV四分位数进行分组,利用logistic回归分析冠脉钙化与ba PWV的相关性。结果:研究人群中CACS>0组87例(15.9%),CACS=0组459例(84.1%)。其中CACS>0组在年龄、BMI、高血压、收缩压、总胆固醇、低密度脂蛋白及糖尿病方面均高于CACS=0组。同时,CACS>0组ba PWV比CACS=0组高(27.6%vs.24.2%,35.6%vs.23.1%),两组间差异有统计学意义(P=0.011),并且Logistic回归发现,绝经女性年龄(OR=1.094,95%CI 1.039-1.152,P<0.001)、高血压(OR=1.933,95%CI 1.092-3.422,P=0.024)、ba PWV第三分位数(OR=2.435,95%CI1.141-5.196,P=0.021)、ba PWV第四分位数(OR=3.323,95%CI 1.594-6.930,P=0.001)是冠脉钙化的独立危险因素。结论:绝经女性ba PWV升高与CACS相关,ba PWV可以作为一种评估冠脉钙化程度和心血管风险的有效手段得以应用。

Objective： To assess the association between coronary artery calcium scoring（CACS）and brachial ankle pulse wave velocity（ba PWV）in post-menopause women. Methods： We collected a total of 546 post-menopausal women who could carry out CACS examination and had no cardiovascular disease from 1,918 people community people as an example. And these women were underwent examinations of questionnaire interview,anthropometric measurements,biochemical indexes,ba PWV testing and CACS assessment.According to CACS,we divided study population into two groups： CAC=0 group and CAC〉0 group,and then we also divided study population into 4 categories according to ba PWV quantiles. After that,the association between ba PWV and CAC was analyzed by logistic regression. Results： There are 87 people（15.9 %）in CAC〉0 group and 459 people（84.1 %）in CAC=0 group. And compared with the CAC=0 group,the CAC〉0 group had obvious higher rates in age,BMI,hypertension,systolic blood pressure,total cholesterol,low density lipoprotein and diabetes（P〈0.05）. And the higher prevalence of ba PWV in post-menopausal women was in CAC〉0 group（27.6 %vs. 24.2 %,35.6 % vs. 23.1 % respectively,P=0.011）. From logistic regress analysis,we found age（OR=1.094,95 %CI 1.039-1.152,P〈0.001）,hypertension（OR=1.933,95 %CI 1.092-3.422,P=0.024）,ba PWV 3rd quantile（OR=2.435,95 %CI 1.141-5.196,P=0.021）and ba PWV 4th quantile（OR=3.323,95 %CI 1.594-6.930,P=0.001）were independent of CAC risk factors. Conclusion： Higher ba PWV was significantly associated with the extent of CAC in post-menopausal women. ba PWV can be used as an effective tool to assess the extent of coronary artery calcium and cardiovascular risk.