氨曲南联合恩替卡韦对肝硬化原发性腹膜炎患者血清甲状腺激素水平及临床疗效的影响

Effects of Aztreonam combined with Entecavir on Serum Levels of Thyroid Hormone in Patients with Hepatitis B Liver Cirrhosis Primary Peritonitis and Its Clinical Efficacy

目的:探讨氨曲南联合恩替卡韦对乙肝肝硬化原发性腹膜炎患者血清甲状腺激素水平及临床疗效的影响。方法:选择于我院就诊的乙肝肝硬化原发性腹膜炎患者60例,根据电脑生成的随机数字表将所有患者随机分为实验组和对照组,每组各30例,对照组患者给予氨曲南进行治疗,实验组患者在对照组的基础上联合应用恩替卡韦进行治疗。比较治疗前后两组患者血清甲状腺激素、中性粒细胞比例、血白细胞及腹水细胞水平,并对治疗前后两组患者的体重、腹围及24 h尿量进行记录。结果:与治疗前相比,两组患者血清TSH水平、体重、腹围均降低,FT3、FT4、T3、T4水平及24 h尿量升高(P<0.05);与对照组相比,实验组患者血清TSH水平、体重、腹围较低,FT3、FT4、T3、T4水平及24h尿量较高(P<0.05);临床总有效率较高(P<0.05)。结论:氨曲南联合恩替卡韦对乙肝肝硬化原发性腹膜炎具有较好的临床疗效,推测其机制与改善甲状腺激素水平,降低炎症反应有关。

Objective： To investigate the effects of aztreonam combined with entecavir on the levels of serum thyroid hormone and its clinical efficacy for patients with hepatitis B liver cirrhosis primary peritonitis. Methods： 60 patients with hepatitis B liver cirrhosis primary peritonitis who were treated in our hospital were selected and randomly divided into experiment group and control group,with 30 cases in each group. Patients in the control group were treated with aztreonam,patients in the experiment group were treated with entecavir on the base of the control group. The serum thyroid hormone,neutrophils ratio,blood white cells and ascites cell levels of the two groups were compared before and after treatment,and the body weight,abdominal circumference and 24 h urine volume of the two groups were recorded before and after treatment. Results： Compared with before treatment,the serum TSH level,body weight and abdominal circumference of the two groups decreased,and the FT3,FT4,T3 and T4 levels and 24 h urine volume increased（P〈0.05）; compared with the control group,the serum TSH level,body weight and abdominal circumference of the experiment group were lower,and the FT3,FT4,T3,T4 levels and 24 h urine volume were higher（P〈0.05）; the clinical total effective rate of the experiment group was higher than that of the control group（P〈0.05）. Conclusion： Aztreonam combine with entecavir in the treatment of patients with hepatitis B liver cirrhosis primary peritonitis has a better clinical efficacy,which could be related to the improvement of the thyroid hormone level and the decrease of the inflammatory reaction.