阿替普酶静脉溶栓后发生早期神经功能恶化的研究进展

Study Progress of Early Neurological Deterioration Following Intravenous Thrombolysis with Alteplase

尽管多数急性缺血性卒中患者经阿替普酶静脉溶栓治疗后症状有所缓解,仍有相当一部分患者经历早期神经功能恶化(early neurological deterioration,END),症状进一步加重。目前学术界对于END的定义尚未统一,因此导致END的发生率不尽相同。关于END确切病因、危险因素以及相关病理生理机制仍是学术界讨论的热点。END的发生强烈提示患者3个月预后不良。本文就以上内容进行综述。

Although the majority of patients with acute ischaemic stroke tends to improve after intravenous thrombolysis with alteplase, there are still certain portion of patients experiencing early neurological deterioration （END） with aggravated symptoms. The deifnition of END still haven’t been uniifed, so that there are differences of reported incidence. The precise causes and risk factors of END with clear underlying pathophysiology remain as the hotspot topic to be discussed. In this paper, all of above mentioned contents were reviewed.