摘要
在无添加催化剂、乙醇和水作混合溶剂的碱性体系中,苯胺类化合物和苄基卤化物经过反应,高选择性地得到了双苄基化产物。苯胺类化合物转化为各类叔胺且产率高达99%。该反应具有无需添加催化剂、反应时间短、产率高、绿色经济以及底物范围广等优点。同时根据反应结果提出了该反应可能的反应机理。
A highly selective dialkylation reaction of anilines with benzyl halides was developed in aqueous alkaline alcohol solu- tion without catalysts. Various symmetrical tertiary amines could be obtained using the above-mentioned synthetic strategy with yields up to 99%. The advantages of this protocol include short reaction duration ,high yields of the targeted products, safe aque- ous medium,no use of catalysts,and wide acceptance of reactants. A rational mechanism was also proposed based on the facts of experimental observations.
作者
王锐
魏小红
杜正银
WANG Rui WEI Xiao-hong DU Zheng- yin(College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, Chin)
出处
《化学试剂》
CAS
北大核心
2017年第3期235-240,共6页
Chemical Reagents
基金
国家自然科学基金资助项目(20702042
21262028)
甘肃省自然科学基金资助项目(1208RJZA140)