水相中非催化芳胺的高选择性双苄基化

Catalyst-free and Highly Selective N,N-Dibenzylation of Anilines in Aqueous Phase

在无添加催化剂、乙醇和水作混合溶剂的碱性体系中,苯胺类化合物和苄基卤化物经过反应,高选择性地得到了双苄基化产物。苯胺类化合物转化为各类叔胺且产率高达99%。该反应具有无需添加催化剂、反应时间短、产率高、绿色经济以及底物范围广等优点。同时根据反应结果提出了该反应可能的反应机理。

A highly selective dialkylation reaction of anilines with benzyl halides was developed in aqueous alkaline alcohol solu- tion without catalysts. Various symmetrical tertiary amines could be obtained using the above-mentioned synthetic strategy with yields up to 99%. The advantages of this protocol include short reaction duration ,high yields of the targeted products, safe aque- ous medium,no use of catalysts,and wide acceptance of reactants. A rational mechanism was also proposed based on the facts of experimental observations.