阿奇霉素联合红霉素及盐酸氨溴索雾化吸入治疗肺炎临床效果分析

Azithromycin combined with erythromycin and ambroxol hydrochloride atomization inhalation in treatment of pneumonia:a analysis of clinical effect

目的:探究阿奇霉素联合红霉素及盐酸氨溴索雾化吸入治疗肺炎的临床效果。方法:选取某院收治的150例肺炎患者,采取随机双盲法将患者分为观察组(75例)与对照组(75例),对照组患者予以阿奇霉素联合盐酸氨溴索雾化吸入治疗,观察组患者在对照组治疗基础上联合红霉素治疗,观察对比2组患者临床疗效及不良反应情况、肺部啰音消失时间、退热时间、止咳时间、住院时间。结果:观察组患者治疗总有效率为97.33%,总不良反应率为1.33%,对照组分别为86.67%,2.67%,观察组总有效率显著高于对照组,差异具有统计学意义(P<0.05),而2组不良反应均较少,差异无统计学意义(P>0.05);观察组患者治疗后肺部啰音消失时间、退热时间、止咳时间、住院时间均短于对照组,差异具有统计学意义(P<0.01)。结论:阿奇霉素联合红霉素及盐酸氨溴索雾化吸入治疗肺炎临床效果良好,患者恢复快,不良反应少,安全性高,具有较高临床应用以及推广价值。

Objective： To explore the clinical effect of azithromycin combined with erythromycin and ambroxol hydrochloride atomization inhalation in treatment of pneumonia. Methods： 150 patients with pneumonia were selected and randomly divided into an observation group and a control group,75 cases in each. Patients in the control group were given azithromycin combined with ambroxol hydrochloride atomization inhalation for the treatment. Patients in the observation group were treated with the above therapy added with erythromycin. The two groups of patients were observed and compared in terms of clinical effect,adverse reactions,time when pulmonary rale disappeared,the fever came down,the cough stopped and the length of hospital stay. Results： For the observation group,the total effective rate was 97. 33%,and the adverse reaction rate was 1. 33%,while the rates were 86. 67% and 2. 67% respectively for the control group. The total effective rate of the observation group was significantly higher than that of the control group. The difference was statistically significant（ P〈0. 05）. As for the adverse reactions,the two groups had no statistically significant difference（ P〈0. 05）.The observation group showed better results after treatment in terms time when pulmonary rale disappeared,the fever came down,the cough stopped and the length of hospital stay. The difference was statistically significant（ P 0. 01）. Conclusion： Azithromycin combined with erythromycin and ambroxol hydrochloride atomization inhalation in treatment of pneumonia has the advantages of better clinical effect,rapid recovery,less adverse reaction,and high security. It is worth clinical application and popularizatio.