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甲基化抑制药及在肾癌治疗中的应用研究进展 被引量:1

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摘要 肾癌是泌尿系肿瘤中居第二位的常见肿瘤,且发病率呈逐年上升趋势。一旦肾癌发生远处转移,其5年生存率不足20%。在肾癌发生、发展过程中,存在多种DNA甲基化异常,DNA甲基化成为除DNA突变和缺失外,导致抑癌基因失活的最重要机制之一。本文就近年来甲基化抑制药及在肾癌治疗中的应用进展综述如下。
机构地区 解放军第
出处 《人民军医》 2017年第3期302-305,共4页 People's Military Surgeon
基金 福建省漳州市科技基金项目(ZZ2013J27)
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