卵巢癌患者血清Galectin-3水平及诊断价值研究

The serum levels of Galectin-3 in patients with ovarian cancer and its clinical diagnostic value

目的观察卵巢癌患者血清半乳糖苷酶-3(Galectin-3)水平,并探讨其用于卵巢癌诊断的临床价值。方法纳入2010年6月至2015年12月就诊的初治卵巢癌患者92例,并设置良性卵巢肿瘤组(n=44)及健康对照组(n=43)。患者初次就诊时收集一般情况并检测血清CA125及HE4,收集剩余血清检测Galectin-3水平。分析Galectin-3与临床检测指标的相关性,并使用ROC曲线评估其用于卵巢癌的诊断价值。结果卵巢癌患者Galectin-3[(1.64±0.68)ng/ml]显著高于良性卵巢肿瘤组[(0.86±0.42)ng/ml]及健康对照组[(0.69±0.20)ng/ml],临床分期较高及存在远处转移患者Galectin-3水平更高。卵巢癌组中,Galectin-3与CA125(r=0.431,P<0.001)、HE4(r=0.331,P=0.001)及临床分期(rs=0.431,P<0.001)显著正相关。Galectin-3单独诊断卵巢癌的AUC为0.861(95%CI:0.804~0.918),其联合CA125及HE4的AUC为0.916(95%CI:0.871~0.961)。结论卵巢癌患者血清Galectin-3显著升高,且与临床分期显著相关。Galectin-3联合CA125及HE4可提高对卵巢癌的诊断效能。

Objective To investigate the serum levels of Galectin-3 and its clinical diagnostic value in patients with primary ovarian cancer .Methods A total of 92 patients with ovarian cancer who were treated from June 2010 to December 2015were enrolled in the study as observation group , moreover,benign ovarian tumor group （ n =44） and control group （43 healthy subjects） were set up.The general conditions of patients were recorded in their first visiting ,and the serum levels of CA125 ,HE4 and Galectin-3 were detected .Moreover the correlation between Galectin-3 and clinical parameters was analyzed . The ROC curve was used to evaluate the diagnositc valve of Galectin-3 in ovarian cancer .Results The serum levels of Galectin-3 in observation group [（1.64 ±0.68） ng/ml] were significantly higher than those in benign ovarian tumor group [（0.86 ±0.42） ng/ml] and control group [0.69 ±0.20）ng/ml],and the serum levels of Galectin-3 were even higher in patients with higher clinical stage and with distant metastases .In observation group ,Galectin-3 was positively correlated to CA125 （ r =0.431, P 〈0.01）,HE4 （ r =0.331, P 〈0.01） and clinical stages （RS=0.431, P 〈0.01）.The AUC of Galectin-3 in single index diagnosis group was 0.861 （95%CI：0.804～0.918）,however,which in combination diagnosis of Galectin-3 with HE4 and CA125 was 0.916 （95%CI：0.871 ～0.961）.Conlcusion The serum levels of Galectin-3 are obviously increased in patients with ovarian cancer ,moreover ,which are closely correlated with clinical stages .The combination diagnosis of Galectin-3 with CA125 and HE4 can enhance diagnostic efficacy for ovarian cancer .