摘要
目的通过对慢性乙肝患者不同年龄段血清甲胎蛋白异质体3(AFP-L3)%>10%阳性率的比较,探讨肝癌的高发年龄段,以提前干预,早期治疗。方法选择门诊或住院慢性乙肝患者174例作为研究对象,根据患者年龄分为<40岁,40~50岁,51~60岁,>60岁4组,比较4组AFP-L3%>10%的阳性率,同时对不同性别各年龄AFPL3检出及AFP-L3%>10%比率进行比较。结果 174例慢性乙肝患者中,48.9%%检出了AFP-L3,AFP-L3未检出的比例为51.1%。<40岁组和51~60岁组AFP-L3%>10%的比例高于其他组,差异有统计学意义(P<0.05),与AFP-L3%>10%总的阳性率(27%)比较,差异无统计学意义(P>0.05)。男性患者51~60岁AFP-L3%>10%检出率为29.4%,明显高于其他各年龄段和AFP-L3%>10%总检出率,差异有统计学意义(P<0.05)。女性患者51~60岁AFP-L3%>10%检出率为40.0%,与<40岁比较,差异无统计学意义(P>0.05),但与其他年龄段比较,差异有统计学意义(P<0.05),且显著高于AFP-L3%>10%总检出率(P<0.05)。结论慢性乙肝患者既要重视对50~60岁年龄段慢性乙肝人群的重点监测,也要注意对40~50岁慢性乙肝患者的提前干预和动态监测,以做到早期发现,早期治疗,为患者赢得尽可能长的生存空间。
Objective To observe the changes of the positive rate of serum alpha fetoprotein ( AFP-L3)%〉10%in different age groups of patients with chronic hepatitis B , and to explore its significance .Methods One hundred and seventy-four patients with chronic hepatitis B who were treated in our hospital from January 2015 to May 2016 were enrolled in the study.These patients were divided into four age groups: 〈40 years group,40 to 50 years group,51~60 years group,〉60 years group .The detection rate of AFP-L3 and positive rate of AFP-L3%〉10%were observed and compared among the four groups.Results Among 174 patients with chronic hepatitis B , the positive rate of AFP-L3 accounted for 48.9%, and negative rate of AFP-L3 accounted for 51 .1%.The proportion of AFP-L3%〉10% in 〈40 years group and 40 to 50 years group was significantly higher than the other two groups ( P 〈0.05).The detection rate of AFP-L3%〉10%in male patients in 51~60 years group was 29.4%, which was significantly higher than that in the other three groups , moreover, the total detection rate of AFP-L3 was also significantly higher than that in the other three groups ( P 〈0 .05 ) .The detection rate of AFP-L3%〉10%in female patients in 51~60 years group was 40.0%,there was no significant difference ,as comapred with that in 〈40 years group ( P 〉0.05), however, there was significant difference ,as comapred with the other groups ( P 〈0.05), moreover,which was significantly higher than total detection rate of AFP-L3%〉10% ( P 〈0.05).Conclusion Much attention should be paid to the monitoring of patients with chronic hepatitis B in 50~60 years group,moreover, to the early intervention and dynamic monitoring of patients in 40~50 years group , for early diagnosis ,early treatment and survival time as long as possible .
出处
《河北医药》
CAS
2017年第2期186-189,193,共5页
Hebei Medical Journal
关键词
肝炎
乙型
慢性
甲胎蛋白异质体
年龄
性别
hepatitis B
chronic
alpha-fetoprotein heteroplasmon
age
sex