慢性乙肝患者不同年龄组AFP-L3%>10%阳性率变化的相关性研究

Significance of the changes of positive rate of AFP-L3% > 10% in different age groups of patients with chronic hepatitis B

目的通过对慢性乙肝患者不同年龄段血清甲胎蛋白异质体3(AFP-L3)%>10%阳性率的比较,探讨肝癌的高发年龄段,以提前干预,早期治疗。方法选择门诊或住院慢性乙肝患者174例作为研究对象,根据患者年龄分为<40岁,40~50岁,51~60岁,>60岁4组,比较4组AFP-L3%>10%的阳性率,同时对不同性别各年龄AFPL3检出及AFP-L3%>10%比率进行比较。结果 174例慢性乙肝患者中,48.9%%检出了AFP-L3,AFP-L3未检出的比例为51.1%。<40岁组和51~60岁组AFP-L3%>10%的比例高于其他组,差异有统计学意义(P<0.05),与AFP-L3%>10%总的阳性率(27%)比较,差异无统计学意义(P>0.05)。男性患者51~60岁AFP-L3%>10%检出率为29.4%,明显高于其他各年龄段和AFP-L3%>10%总检出率,差异有统计学意义(P<0.05)。女性患者51~60岁AFP-L3%>10%检出率为40.0%,与<40岁比较,差异无统计学意义(P>0.05),但与其他年龄段比较,差异有统计学意义(P<0.05),且显著高于AFP-L3%>10%总检出率(P<0.05)。结论慢性乙肝患者既要重视对50~60岁年龄段慢性乙肝人群的重点监测,也要注意对40~50岁慢性乙肝患者的提前干预和动态监测,以做到早期发现,早期治疗,为患者赢得尽可能长的生存空间。

Objective To observe the changes of the positive rate of serum alpha fetoprotein （ AFP-L3）%〉10%in different age groups of patients with chronic hepatitis B , and to explore its significance .Methods One hundred and seventy-four patients with chronic hepatitis B who were treated in our hospital from January 2015 to May 2016 were enrolled in the study.These patients were divided into four age groups： 〈40 years group,40 to 50 years group,51～60 years group,〉60 years group .The detection rate of AFP-L3 and positive rate of AFP-L3%〉10%were observed and compared among the four groups.Results Among 174 patients with chronic hepatitis B , the positive rate of AFP-L3 accounted for 48.9%, and negative rate of AFP-L3 accounted for 51 .1%.The proportion of AFP-L3%〉10% in 〈40 years group and 40 to 50 years group was significantly higher than the other two groups （ P 〈0.05）.The detection rate of AFP-L3%〉10%in male patients in 51～60 years group was 29.4%, which was significantly higher than that in the other three groups , moreover, the total detection rate of AFP-L3 was also significantly higher than that in the other three groups （ P 〈0 .05 ） .The detection rate of AFP-L3%〉10%in female patients in 51～60 years group was 40.0%,there was no significant difference ,as comapred with that in 〈40 years group （ P 〉0.05）, however, there was significant difference ,as comapred with the other groups （ P 〈0.05）, moreover,which was significantly higher than total detection rate of AFP-L3%〉10% （ P 〈0.05）.Conclusion Much attention should be paid to the monitoring of patients with chronic hepatitis B in 50～60 years group,moreover, to the early intervention and dynamic monitoring of patients in 40～50 years group , for early diagnosis ,early treatment and survival time as long as possible .