吡贝地尔联合艾司西酞普兰对帕金森患者运动功能及认知功能的影响

Effects of piribedil combined with escitalopram oxalate on motor function and cognitive function of patients with Parkinson

目的探讨吡贝地尔联合艾司西酞普兰对改善帕金森患者运动功能及认知功能的治疗效果。方法按患者就诊时病例号对照数字表分别纳入单用药组(单用吡贝地尔)或联合用药组(吡贝地尔+艾司西酞普兰),每组55例。采用帕金森综合评定量表(UPDRS)一至四部分、Hoehn-Yahr分期情况对患者治疗效果及运动功能进行评估,采用简易智能量表(MMSE)、韦氏记忆量表(WMS)、残图命名(DPN)、画钟测验(CDT)对患者认知功能进行评估,记录2组患者服药期间不良反应发生情况。结果联合用药组与单用药组在治疗有效率(83.6%vs 56.4%)及治疗后Hoehn-Yahr分期中Ⅰ~Ⅱ级比例(85.5%vs 69.1%)差异有统计学意义(P<0.05);同时,联合用药组与单用药组在UPDRSⅡ、UPDRSⅢ及UPDRS总分上差异有统计学意义(P<0.05),此外,联合用药组与单用药组在WMS、DPN、CDT差异有统计学意义(P<0.05),但2组在药物不良反应率差异无统计学意义(P<0.05)。结论吡贝地尔联合艾司西酞普可能有助于改善帕金森患者运动功能的同时,增强认知功能的恢复。

Objective To observe the effects of piribedil combined with escitalopram oxalate on motor function and cognitive function of patients with Parkinson .Methods One hundred and fifty-five patients with Parkinson were divided into two groups according to random number table： single medication group （ piribedil only ） and combination medication group （ piribedil＋escitalopram oxalate ） , with 55 patients in each group .The therapeutic effects and motor function of patients were evaluated by UPDRS Part Ⅰ-Ⅳ,Hoehn-Yahr staging,and the cognitive function of patients was assessed by MMSE ,WMS, DPN,CDT,moreover, the adverse reactions during medication were observed and comapred between two groups .Results There were significant differences in the effective rates （83.6%vs 56.4%） and the proportion of Hoehn-Yahr stagingⅠ～Ⅱ（85.5%vs 69.1%） after treatment between two groups （ P 〈0.05）.Meanwhile, there were significant differences in the total scores of UPDRS Ⅱ, UPDRS Ⅲ and UPDRS between two groups （ P 〈0.05 ）.Besides, there were significant differences in WMS, DPN,CDT between two groups （ P 〈0.05）.However there were no significant differences in the incidence rates of adverse reactions between two groups （ P 〉0.05）.Conclusion The piribedil combined with escitalopram oxalate may improve the motor function of patients with Parkinson , moreover , which may improve the recovery of cognitive function.