急性心肌梗死患者经皮冠状动脉支架植入术术后血清soL-CXCL16及NT-proBNP水平变化分析

The study on the change of serum levels of soL-CXCL16 and NT-proBNP in patients with percutaneous coronary stenting following PCI

目的研究冠心病患者实施经皮冠状动脉支架植入术(PCI)前后血清可溶性趋化因子16(soL-CXCL16)和N-端脑钠肽前体(NT-proBNP)水平变化情况及临床价值。方法选取77例实施PCI的冠心病患者。采用酶联免疫吸附试验(ELISA)测定血清soL-CXCL16、NT-proBNP和肌钙蛋白(cTnT)的水平,应用Pearson相关性分析方法检测soL-CXCL16和NT-proBNP与cTnT的关系。结果与PCI术前相比,血清中soL-CXCL16水平在术后0.5h达到峰值,在术后2.0h开始下降,在术后24.0h回落至术前水平。而血清NT-proBNP在术后0.5h开始升高,至术后24.0h显著升高(P<0.05)。soL-CXCL16和NT-proBNP与心肌缺血呈正相关(P<0.01)。结论监测患者术前及术后血清soL-CXCL16和NT-proBNP水平的变化,为评估PCI术后的预后提供依据。

Objective To investigate the clinical value of the variety of serum levels of soL-CXCL16 and NT-proBNP peripercutaneous coronary intervention（PCI）in patients with acute myocardial infarction（AMI）.Methods A total of 77 cases received PCI were selected to research group.And the contemporaneous 30 healthy persons were chosen to control group.The serum levels of soL-CXCL16,NT-proBNP and cTnT were detected by ELISA.The relationships of soL-CXCL16 and NT-proBNP to cTnT were detected by Pearson linear correlation analysis.Results Compared to pre-PCI,the serum levels of CXCL16 were rising to the peak point at 0.5hpost-PCI,and were decreasing from 2.0hpost-PCI,then the serum levels of CXCL16 were declining to the levels of pre-PCI at 24.0hpost-PCI（P〈0.05）.And the serum levels of NT-proBNP were rising from 0.5hpost-PCI,and the peak point was at 24.0h post-PCI（P〈0.05）.The postive relationships of the serum levels of CXCL16 and NT-proBNP to the serum levels of cTnT were confirmed by Pearson linear correlation analysis（P〈0.01）.Conclusion Monitoring of soL-CXCL16 and NT-proBNP for patients with percutaneous coronary stenting could provide foundation for prognosis evaluation of PCI.