阿司匹林联合阿托伐他汀对UAP患者血清sCD40L和MMP-2的影响

Effect of combination of aspirin and atorvastatin on the concentration of serum sCD40L, MMP-2 in unstable angina pectoris patients

目的探讨阿司匹林联合阿托伐他汀对不稳定型心绞痛(UAP)患者血清中白细胞分化抗原40配体(s CD40L)和基质金属蛋白酶-2(MMP-2)的影响。方法将92例UAP患者随机分为对照组(n=46)和观察组(n=46)。2组患者均在常规药物的治疗基础上,对照组加用阿司匹林(100 mg/d,早餐后顿服),观察组在对照组的基础上加用阿托伐他汀(10 mg/次,每晚1次)。疗程均为4周,测定两组患者治疗前后血清s CD40L和MMP-2水平,并观察心绞痛疗效、治疗前后血脂水平。结果对照组治疗总有效率为67.39%,明显低于观察组的86.96%,差异有统计学意义(P<0.05)。两组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白C(LDL-C)、s CD40L和MMP-2水平均较治疗前显著降低,差异均有统计学意义(P<0.05),且治疗后观察组上述指标水平均明显低于对照组,差异有统计学意义(P<0.05)。结论阿司匹林联合阿托伐他汀可改善UAP的临床症状,可能与通过降低患者血清中s CD40L和MMP-2浓度,以及血脂的水平有关。

Objective To discuss the effect of combination of atorvastatin and aspirin on the concentration of serum soluble CD40 ligand（sCD40L）,matrix metalloproteinase（MMP）-2 in unstable angina pectoris（UAP）patients. Methods 92 patients with UAP were randomly divided into 2 groups：an observation group（n=46）and control group（n=46）. Patients in the control group were treated with aspirin 100 mg/d based on routine medicine. Patients in the observation group were treated with atorvastatin 10 mg/d based on medicine used in the control group. Both groups were treated for 4 weeks. The therapeutic effect was observed and the levels of serum sCD40L,MMP-2 and lipid were detected by ELISA before and after treatment.Results The differences in the angina pectoris curative effect,total effective rate between the observation group and the control group were statistically significant（P〈0.05）. The levels of TC,TG,LDL-C,sCD40L and MMP-2 in the two groups after treatment were significantly decreased compared with those before treatment（P〈0.05）,which in the observation group after treatment were obviously lower than those in the control group,and the differences were statistically significant（P〈0.05）.Conclusion Combination of atorvastatin and aspirin can improve angina symptoms,which may be related to the decreasing of the concentration of sCD40L,MMP-2 and lipid levels.