重氮膦酸酯研究进展

Research Progress in Diazophosphonates

重氮化合物是一类重要的卡宾前体,在有机合成中应用广泛。重氮膦酸酯是含磷重氮化合物,与重氮羧酸酯相比,重氮膦酸酯具有一些特殊的反应类型和反应性质。由于重氮膦酸酯具有丰富的化学转化形式以及含磷功能化合物潜在的生物和药物活性,近年来其合成方法以及反应性质成为化学家们的研究热点。本文综述了近年来重氮膦酸酯的研究和应用进展。

Diazo compounds are an important class of carbene precursors,widely used in organic synthesis towards different kinds of functional organic molecules.As one of the most important diazo compounds,diazophosphonates possess some special reaction types and reaction properties.Because of organic phosphorous compounds exhibit extensive bioactivities and pharmaceutic activities,the research of diazophosphonates has attracted lots of attentions of scientists.In this paper,the recent development in the synthese and applications of diazophosphonates are summarized.