左心耳封堵器临床研究进展

Progress in clinical research of left atrial appendage occluder

心房颤动是常见心律失常,是老年人缺血性脑卒中的主要原因之一。左心耳是非瓣膜性房颤(NVAF)形成血栓的主要部位。研究表明封堵左心耳可有效地减少NVAF患者缺血性脑卒中发作,其疗效不亚于华法林预防治疗作用。理想的左心耳封堵器是完成左心耳封堵的关键因素。经过数十年研究,目前临床上常用的左心耳封堵器有Watchman封堵器、ACP封堵器,还有部分封堵器处于临床前试验研究阶段。该文就目前左心耳封堵器研究和临床应用现状作一简要综述。

Atrial fibrillation （AF） is a common kind of arrhythmia, it is one of the main reasons causing ischemic stroke in aged patients. Left atrial appendage is the primary site where the thrombus is formed in non-valvular atrial fibrillation （NVAF） patients. Recent researches have indicated that occlusion of left atrial appendage can effectively reduce the occurrence of ischemic stroke in NVAF patients, its curative effect is no less than the preventive treatment effect of warfarin. The use of an ideal left atrial appendage occluder is the key to ensure a successful occlusion of the left atrial appendage. After decades of research, several left atrial appendage occluders have been developed, among them Watchman occluder and Amplatzer cardiac plug （ACP） are commonly used nowadays in clinical practice, and some kinds of occluder are still at their experimental research stage. This article aims to make a brief introduction about the current status of the study and the clinical application of left atrial appendage oecluder.