MRS定量评价腰椎间盘退变

MRS in quantitative assessment of lumbar discs degeneration

目的探讨MRS技术定量评价腰椎间盘退变程度的价值。方法对82例腰痛患者行腰椎MR常规扫描,采用T2WI矢状位图像进行Pfirrmann分级;采用MRS技术检测腰椎间盘髓核的氮-乙酰氨基(N-acetyl)峰下面积、水(Water)峰下面积及二者峰下面积比值,分析MRS测量值与Pfirrmann退变分级、患者年龄间的相关性。结果 82例患者中,204个椎间盘可获得MRS测量值,其中Ⅱ、Ⅲ、Ⅳ、Ⅴ级椎间盘数目分别为89个、73个、39个、3个,髓核区N-acetyl峰下面积、Water峰下面积、N-acetyl/Water峰下面积比值与腰椎间盘Pfirrmann分级呈负相关(r_s=-0.460、-0.204、-0.526,P均<0.05)。<30岁、30~39岁、40~49岁、50~59岁、>59岁的患者中,取得MRS测量值的椎间盘数目分别为62个、25个、37个、51个、29个,腰椎间盘髓核区N-acetyl峰下面积、N-acetyl/Water峰下面积比值与年龄段呈负相关(r_s=-0.247、-0.385,P均<0.05)。结论 MRS技术可用以定量检测腰椎间盘的退变程度。

Objective To evaluate the value of MRS in quantitative assessment of degeneration of lumbar discs.Methods Totally 82 patients with lumbago underwent lumbar MR scanning.All the discs were classified with Pfirrmann grades in the sequences of sagittal T2WI.The area under N-acetyl peak,under water peak and the ratio of N-acetyl/Water were measured by MRS.Correlation between MRS values and Pfirrmann grade,age were analyzed.Results In 82 patients,204 lumbar discs were measured by MRS.There were 89,73,39,3 discs in PfirrmannⅡ,Ⅲ,Ⅳ,Ⅴrespectively.The areas of N-acetyl,water peak and N-acetyl/Water ratio of nucleus region were positively correlated with Pfirrmann grading,respectively（r_s=-0.460,-0.204,-0.526,all P〈0.05）.There were 62,25,37,51,29 discs in patients aged 〈30,30—39,40—49,50—59,〉59years respectively.The ares of N-acetyl peak,N-acetyl/Water ratio of nucleus region was negatively correlated with the age（r_s=-0.247,-0.385,both P〈0.05）.Conclusion MRS can be used for quantitative assessment of lumbar discs degeneration.