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健康人群全身动态^(13)N-NH_3·H_2O PET/CT显像^(13)N-NH_3·H_2O的生物分布及辐射吸收剂量评估 被引量:2

Biodistribution and estimation of radiation-absorbed doses in humans for ^(13)N-ammonia PET/CT
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摘要 目的探讨健康人群^(13)N-NH_3·H_2O PET/CT显像中^(13)N-NH_3·H_2O的生物分布和主要器官的辐射吸收剂量。方法对5名健康志愿者在注射666~814 MBq ^(13)N-NH_3·H_2O后进行全身PET/CT扫描,获得每名受试者的连续动态图像。通过CT二维轴位图像手动勾画ROI,并在PET图像中找出相应层面,按照医学内照射剂量计算(MIRD)方法评估^(13)N-NH_3·H_2O的吸收剂量。结果心脏、肝及双肾^(13)N-NH_3·H_2O摄取最高,其次为胰腺、脑组织、脾脏和胃。心脏的吸收剂量最高,为(7.14±3.63)×10^(-3) mGy/MBq。受试者全身辐射吸收剂量为(2.11±0.44)×10^(-3) mGy/MBq,全身有效剂量为(6.58±1.23)×10^(-3)mSv/MBq。结论 ^(13)N-NH_3·H_2O作为重要的心肌显像示踪剂,用于人体全身PET/CT显像的辐射剂量是安全的。 Objective To evaluate the biodistribution and radiation-absorbed doses of main organs in healthy people with 13N-ammonia.Methods Five healthy volunteers underwent whole-body PET and CT scans after injection of 666—814MBq of 13N-ammonia.The serial dynamic emission images of each healthy volunteer were acquired.ROI were drawn manually based on the transverse CT images and transferred to the corresponding PET slices.Radiation-absorbed doses were calculated using the medical internal radiation dosimetry(MIRD)method.Results The highest concentrations of 13N-ammonia were found in the heart,liver and kidneys,followed by pancreas,brain,spleen and stomach.The organ of highest absorbed dose was heart with(7.14±3.63)×10^-3 mGy/MBq.The whole-body absorbed dose was(2.11±0.44)×10^-3mGy/MBq.The whole-body effective dose was(6.58±1.23)×10^-3 mSv/MBq.Conclusion As one of the most important myocardial perfusion tracers,the whole-body 13N-NH3·H2O PET appears to be safe for humans.
出处 《中国医学影像技术》 CSCD 北大核心 2017年第3期478-482,共5页 Chinese Journal of Medical Imaging Technology
基金 国家自然科学基金(81271599)
关键词 正电子发射型体层摄影术 辐射剂量 健康人 13N-NH3·H2O Positron-emission tomography Radiation dosage Healthy adult 13N-ammonia
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