摘要
目的探讨健康人群^(13)N-NH_3·H_2O PET/CT显像中^(13)N-NH_3·H_2O的生物分布和主要器官的辐射吸收剂量。方法对5名健康志愿者在注射666~814 MBq ^(13)N-NH_3·H_2O后进行全身PET/CT扫描,获得每名受试者的连续动态图像。通过CT二维轴位图像手动勾画ROI,并在PET图像中找出相应层面,按照医学内照射剂量计算(MIRD)方法评估^(13)N-NH_3·H_2O的吸收剂量。结果心脏、肝及双肾^(13)N-NH_3·H_2O摄取最高,其次为胰腺、脑组织、脾脏和胃。心脏的吸收剂量最高,为(7.14±3.63)×10^(-3) mGy/MBq。受试者全身辐射吸收剂量为(2.11±0.44)×10^(-3) mGy/MBq,全身有效剂量为(6.58±1.23)×10^(-3)mSv/MBq。结论 ^(13)N-NH_3·H_2O作为重要的心肌显像示踪剂,用于人体全身PET/CT显像的辐射剂量是安全的。
Objective To evaluate the biodistribution and radiation-absorbed doses of main organs in healthy people with 13N-ammonia.Methods Five healthy volunteers underwent whole-body PET and CT scans after injection of 666—814MBq of 13N-ammonia.The serial dynamic emission images of each healthy volunteer were acquired.ROI were drawn manually based on the transverse CT images and transferred to the corresponding PET slices.Radiation-absorbed doses were calculated using the medical internal radiation dosimetry（MIRD）method.Results The highest concentrations of 13N-ammonia were found in the heart,liver and kidneys,followed by pancreas,brain,spleen and stomach.The organ of highest absorbed dose was heart with（7.14±3.63）×10^-3 mGy/MBq.The whole-body absorbed dose was（2.11±0.44）×10^-3mGy/MBq.The whole-body effective dose was（6.58±1.23）×10^-3 mSv/MBq.Conclusion As one of the most important myocardial perfusion tracers,the whole-body 13N-NH3·H2O PET appears to be safe for humans.
出处
《中国医学影像技术》
CSCD
北大核心
2017年第3期478-482,共5页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(81271599)
