病理性瘢痕形成相关信号通路的研究进展

Advances in the research of signaling pathway in pathologic scar formation

随着社会经济的发展，在烧／创伤患者的治疗中，外观和功能的恢复越来越受到重视，这对病理性瘢痕的防治提出了更高要求。目前大量研究致力于揭示病理性瘢痕形成机制，探索可能的防治靶点，并取得了较多进展，尤其是在信号通路方面的研究成果为病理性瘢痕的防治提供了更多可能。本文从炎症反应相关信号通路、组织修复相关信号通路、修复终止相关信号通路3个方面进行介绍。

Scar is the natural end of wound healing, but pathologic scar will form with the excessive hyperplasia. The problems which thus come not only include the physiological and psychological disorders caused by the change of appearance or dysfunction, but also include the economic burden for both fami- lies of the patients and society induced by the requirement of plastic or functional reconstruction. The formation of pathologic scars is affected by many factors involved in the process of wound healing, such as excessive inflammation, abnormal tissue repair, and lingering repair termination, which involve a lot of signaling pathways. Current studies show that these signaling pathways are potential sites for the prevention and treatment of pathologic scar. These signaling pathways arc reviewed from the aspects of inflammation-related signaling pathways, tissue repair- related signaling pathways, and repair-termination-related signa- ling pathways.