硅酸铝镁在药剂学领域应用研究进展

Advances in Research on Application of Magnesium Aluminumsilicatein Pharmaceutics

笔者通过从提高片剂的硬度;改善粉体的流动性和防止粉体吸潮结块的作用;油状药物的粉末化;将难溶性结晶药物与硅酸铝镁共同研磨,形成无定型产物,进而提高药物的溶出度;在固体分散制剂以及缓释制剂处方设计的应用等5个方面综述硅酸铝镁在药剂学应用研究的进展,并介绍硅酸铝镁理化特性和安全性评价结果。

The research progress of the application of magnesium aluminum silicate in pharmaceutics was reviewed in this paper.We introduced the physiochemical properties and safety profile evaluations of magnesium aluminum silicate firstly. Then the research progress of the application of magnesium aluminum silicate was reviewed from the following five aspects： firstly,improving the fluidity of powder,increasing the hardness of tablets as well as preventingpowder from moisture caking; secondly,powdering oil-like drugs;thirdly,grinding poorly water-soluble crystalline drugs with magnesium aluminum silicate to form amorphous products,which can improve the dissolution rate of the drugs. In addition,the paper also reviewed the applications of magnesium aluminum silicate in solid dispersions,designing of sustained release formulations and so on.