胰十二指肠切除术后肠内外联合营养与完全胃肠外营养的临床疗效比较

Comparison of clinical efficacy between total enteral nutrition and enteral nutrition combined with parenteral nutrition after pancreaticoduodenectomy

目的比较胰十二指肠切除术后肠内外联合营养与完全胃肠外营养的临床疗效。方法前瞻性收集2012年7月至2015年7月期间笔者所在医院收治的70例行胰十二指肠切除术治疗的患者为研究对象,采用完全随机数字表法将患者随机均分为联合营养组与胃肠外营养组。联合营养组患者接受肠内外联合营养支持,胃肠外营养组患者接受完全胃肠外营养支持。比较2组患者治疗前后的营养指标、其他相关指标以及术后并发症发生率。结果 1营养指标,与治疗前比较,联合营养组和胃肠外营养组患者治疗后1周和治疗后2周的体质量指数(BMI)、白细胞计数、血清白蛋白水平、血清前白蛋白水平及总淋巴细胞计数均有所改善(P<0.05)。治疗前、治疗后1周和治疗后2周,同时点联合营养组和胃肠外营养组患者的BMI、白细胞计数、血清白蛋白水平、血清前白蛋白水平及总淋巴细胞计数比较差异均无统计学意义(P>0.05)。2其他相关指标。联合营养组患者的肛门排气时间、排便时间及住院时间均短于胃肠外营养组,且治疗费用也少于胃肠外营养组(P<0.05)。3并发症发生率。联合营养组的总术后并发症发生率为11.4%(4/35),胃肠外营养组为20.0%(7/35),2组患者的总并发症发生率比较差异无统计学意义(P>0.05)。结论胰十二指肠切除术后使用肠内外联合营养与完全胃肠外营养支持均能取得较好的疗效,但肠内外联合营养支持能够促使患者更快康复,且费用更低,适合在临床上推广。

Objective To compare the clinical efficacy between total enteral nutrition and enteral nutrition combined with parenteral nutrition after pancreaticoduodenectomy. Methods A total of 70 patients who underwent pancreaticoduodenectomy in our hospital from July 2012 to July 2015 were collected prospectively, and all patients were divided into 2 groups randomly： enteral nutrition group and combined nutrition group. Patients in enteral nutrition group received total enteral nutrition, and patients in combined nutrition group received enteral nutrition combined with parenteral nutrition. Compared the nutritional indicators, other related indexes, and morbidity between the 2 groups. Results （1） The nutritional indexes. Compared with before treatment, the body mass index （BMI）, white blood cell count, serum albumin level, serum albumin level, and total lymphocyte count at 1 week and 2 weeks after treatment improved （P〈0.05）. At the same time point （before treatment, 1 week after treatment, and 2 weeks after treatment）, there was no significant in the BMI, white blood cell count, serum albumin level, serum albumin level, and total lymphocyte count between the 2 groups （P〉0.05）. （2） Other related indexes. The anal exhaust time, defecation time, and hospital stay of the patients in the combined nutrition group were shorter than those of enteral nutrition group, and the cost of treatment in combined nutrition group was less than that of the enteral nutrition group （P〈0.05）. （3） Morbidity. There was no significant difference in the total morbidity between the combined nutrition group （ 11.4% （4/35）） and enteral nutrition group （ 20.0% （7/35））, P〉0.05. Conclusion Total enteral nutrition and enteral nutrition combined with parenteral nutrition after pancreaticoduodenectomy both can obtain well curative effect, but enteral nutrition combined with parenteral nutrition can make the patients recover faster with lower cost, which is suitable for promotion.