lncRNA调控肿瘤能量代谢机制的研究进展

Research progress of lncRNA on regulation of energy metabolism in tumor cells

目的总结近年来lncRNA肿瘤能量代谢机制的最新研究进展。方法计算机检索Pub Med、Springer、High Wire等数据库中的相关文献,就近年来长链非编码RNA(lncRNA)调控肿瘤能量代谢机制的研究进展进行综述。结果恶性肿瘤最主要的能量代谢特点就是有氧糖酵解(Warburg效应),lncRNA能够通过对肿瘤细胞糖代谢、谷氨酰胺代谢和脂类代谢途径中的关键环节进行调节,导致肿瘤细胞对葡萄糖摄取增加、谷氨酰胺分解增强及脂质生成增加,从而促进肿瘤的发生和发展。结论目前,大多数lncRNA在肿瘤细胞能量代谢中的功能和调控机制尚不完全清楚,进一步认识和了解肿瘤细胞中与lncRNA相关的能量代谢异常表现出的恶性生物学行为,将有助于为肿瘤的诊断和治疗提供有效的证据及新的思路和途径。

Objective To summarize the latest research progress of tumor energy metabolism regulated by long non-coding RNA （lncRNA）. Method Literatures about the recent studies on the bioenergetic metabolic mechanisms regulated by lncRNA in tumor cells were reviewed according to the results searched from PubMed database, Springer database, HighWire database, and so on. Results Aerobic glycolysis （Warburg effect） was regarded as the most important characteristics of energy metabolism in tumor cells, lncRNA could regulate many key progressions involved energy metabolism in tumor cells, such as glucose metabolism, lipid metabolism, and glutamine metabolism, resulting in accelerated uptake of glucose, decomposition of glutamine, and formation of lipid. Condusions The functions and mechanisms of energy metabolism in tumor cells regulated by lncRNA are entirely unclear. The role of lncRNA played in cancer needs to be understood, which may contribute to new tumor biomarker detection and effective treatment strategies.