中医药对吸烟所致冠状动脉内皮损伤的干预作用研究被引量：1

Intervention Study on the Effect of Chinese Medicine on Smoking-induced Coronary Artery Endothelial Injury

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摘要目的:通过观察通脉1号方水丸对吸烟患者血管内皮损伤的影响,为改善吸烟者血管内皮功能提供中医药干预的新策略。方法:将行冠脉CT证实为存在冠状动脉粥样硬化且中医辨证为热毒血瘀证120例吸烟者随机分为对照组与治疗组各60例,对照组患者给予常规治疗,治疗组在常规治疗的基础上采用中药水丸口服,治疗3个月。观察两组患者治疗前后内皮素-1(ET-1)、NO指标的变化。结果:两组患者治疗前后ET-1指标差异具有统计学意义(P<0.05),NO指标结果差异具有显著统计学意义(P<0.01)。结论:中医药干预可改善热毒血瘀型吸烟患者的冠状动脉血管内皮功能。 Objective：By observing the effects of traditional Chinese medicine decoction on smoker＇s endothelial injury of Coronary Artery and Carotid Artery,to provide new intervention strategy of TCM that can improve the endothelial function of smoker.Methods：120smokers belong to heat toxin and blood stasis were devided into 2groups：intervention of Chinese medicine group treated with traditional Chinese medicine decoction,control group that give routine treatment,60 patients in each group,treated for three month.Then the ET-1,NO were observed.Results：After treatment,the ET-1index differences was statistically significant（P〈0.05）,and the NO index results was statistically significant（P〈0.01）.Conclusion：Chinese medicine intervention can improve the endothelial function of coronary artery in patients with heat toxin and blood stasis of smoking.

作者刘志明

机构地区栖霞市中医医院

出处《亚太传统医药》 2017年第6期129-131,共3页 Asia-Pacific Traditional Medicine

关键词吸烟内皮损伤中医药干预内皮素-1 NO Smoking Endothelial Injury Traditional Chinese Medicine Intervention ET-1 NO

分类号 R259 [医药卫生—中西医结合]

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1李天飞.中国烟草控制政策的经济学分析[J].上海经济研究,2004,16(4):46-49. 被引量：5
2裴静静,沈小梅.血管内皮功能的检测方法及意义[J].医学理论与实践,2016,29(1):27-29. 被引量：7

二级参考文献23

1National Cancer Institute (2001). Risks associated with smoking cigarettes with low machine-measured yields of tar and nicotine. Bethesda MD: US Departmant of Health and Human Services, National Institutes of Health, National Cancer Institute.
2Fiore MC,Bailey WC,Cohen SJ et a1(1996). Smoking cessation. Clinical Practice Guideline No. 18. Rockville MD,US Department of Health and Human Services. Agency for Health Care Policy and Research (AHCPR).
3Council of the European Union(2000). Proposal for a directive of the European Parliament and of the Council on the approximation of the laws ,regulations and administrative provisions of the member states concerning the manufacture ,presentation and sale of tobacco products (recast).
4Zhou,Huizhong(2000). Fiscal decentralization and the development of the tobacco industry in China. China Economic Review,Volume11 ,Issue2,pp. 114-133.
5Royal College of Phhsicians (1962), Smoking and Health. In: A report of the Royal College of hysicians on smoking in relation to cancer of the lung and other diseases. London:Pitman Medicalk.
6Furchgott RF,Zawadzki JV.The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine[J].Nature,1980,288(5789):373-376.
7Fish RD,Nabel EG,Selwyn AP,et al.Responses of coronary arteries of cardiac transplant patients to acetylcholine[J].Journal of Clinical Investigation,1988,81(1):21-31.
8Lind L,Berglund L,Larsson A,et al.Endothelial function in resistance and conduit arteries and 5-year risk of cardiovascular disease[J].Circulation,2011,123(14):1545-1551.
9Nohria A,Gerhard-Herman M,Creager MA,et al.Role of nitric oxide in the regulation of digital pulse volume amplitude in humans[J].J Appl Physiol,2006,101(2):545-548.
10Matsuzawa Y,Sugiyama S,Sugamura K,et al.Digital assessment of endothelial function and ischemic heart disease in women[J].Journal of the American College of Cardiology,2010,55(16):1688-1696.