细胞焦亡的分子机制及其在感染性疾病中的作用

Molecular mechanisms of pyroptosis and its role in infectious diseases

细胞焦亡是一种特异性依赖于caspase-1和/或caspase-11活化的致炎性、程序性细胞死亡方式。模式识别受体识别胞内外致病相关的微生物成分,进而启动机体炎性体信号应答,激活细胞焦亡信号通路,释放IL-1β、IL-18等炎症因子,最终诱导细胞炎性死亡。细胞焦亡与微生物感染所致多种疾病的发生发展相关联,细胞焦亡信号通路相关分子的确定,为相关疾病的治疗提供全新的药物靶点。本文就细胞焦亡的分子机制及其在微生物感染相关疾病中的作用作一综述。

Pyroptosis is a highly inflammatory form of programmed cell death mediated by caspase-1 and/or caspase-11. The initiation of pyroptosis has been linked to the recognition of various intracellular （or extracellular） pathogenic microbial components by pattern recognition receptors that trigger the inflammasome response and the subsequent activation of the pyroptosis signal pathway in which proinflammatory cytokines such as IL-1β and IL-18 are released. Recent studies have indicated that pyroptosis is associated with a variety of diseases caused by microbial infections, and identification of the molecules involved in the pyroptosis pathway will provide new targets for therapies to treat those diseases. This paper reviews the molecular mechanisms of pyroptosis and its role in related diseases based on recent studies.