C型利尿钠肽对骨及软骨组织作用的研究进展

Research advances in the effect of C-type natriuretic peptide on bone and cartilage tissue

C型利尿钠肽(C-type natriuretic peptide,CNP)过去一直被认为是调节软骨稳态并参与软骨内成骨的重要调节因子,在动物模型中特异性敲除大鼠CNP基因或者其利尿钠肽受体会导致矮大鼠。相反,当CNP过表达时,CNP基因敲除的大鼠骨发育不良症状得到纠正。体外实验表明外源性CNP能够浓度依赖性地影响软骨细胞的增殖、分化以及细胞外基质的生成。另外有证据表明增强CNP信号系统可预防生长发育迟缓,保护骨关节炎患者软骨。本文将就CNP对骨及软骨组织的相关作用以及其潜在的治疗应用价值进行综述。

Over the past several years, the C-type natriuretic peptide（CNP） has emerged as an important regulator of cartilage homeostasis and endochondral bone growth.In mice, genetic ablation of CNP or its cognate receptor NPRB results in marked dwarfism.Conversely, overexpression of CNP rescued the phenotype of CNP-deficient mice.In vitro studies demonstrated the exogenous CNP influenced chondrocyte differentiation, and proliferation and matrix synthesis at a concentration dependent manner.Evidence indicates that enhanced CNP signaling may prevent growth retardation and protect cartilage in patients with inflammatory joint disease.This review focuses on the role of CNP signaling in bone and cartilage tissue and its potential therapeutic applications.