靳三针结合加味乌梅丸治疗围绝经期失眠的临床观察

Clinical Observation of Jin's Three-needle Combined with Jiawei Wumei Pill in the Treatment of Perimenopausal Insomnia

目的:观察靳三针联合加味乌梅丸治疗围绝经期失眠的效果及安全性。方法:选取我院2015年10月-2016年3月就诊的围绝经期失眠患者165例。按照随机数字表法分为A组(n=41)、B组(n=41)、C组(n=41)和D组(n=42)。A组患者给予艾司唑仑片1 mg,qd;B组患者采用靳三针疗法30 min/次,qd;C组患者给予加味乌梅丸1丸,于早晚餐后温服;D组患者采用靳三针结合加味乌梅丸治疗(方法同B、C组)。4组患者均治疗4周。观察4组患者治疗前后的匹茨堡睡眠质量指数量表(PSQI)评分、改良Kupperman评分、生活质量评分,血清雌二醇(E_2)、卵泡刺激素(FSH)水平,并记录不良反应发生情况。结果:治疗前,上述评分和指标比较,差异均无统计学意义(P>0.05)。治疗后,4组患者PSQI评分、改良Kupperman评分均较治疗前明显降低,且B、C、D组患者明显低于A组,D组患者明显低于B、C组,差异均有统计学意义(P<0.05);4组患者生活质量评分均较治疗前明显升高,且B、C、D组患者明显高于A组,D组患者明显高于B、C组,差异均有统计学意义(P<0.05);B、C、D组患者的E_2水平均较治疗前及A组同期明显升高,FSH水平明显降低,且D组患者改善程度明显优于B、C组,差异均有统计学意义(P<0.05)。A组患者不良反应发生率明显高于B、C、D组,差异有显著统计学意义(P<0.01);但B、C、D组患者不良反应发生率比较,差异无统计学差异(P>0.05)。结论:靳三针结合加味乌梅丸治疗围绝经期失眠患者效果较好,且安全性高。

OBJECTIVE： To observe the effectiveness and safety of Jin＇s three-needle combined with Jiawei wumei pill in the treatment of menopausal insomnia. METHODS： One hundred and sixty-five patients with perimenopausal insomnia were selected from our hospital during Jan. 2015-Mar. 2016, and then divided into group A （n=41）, group B （n=41）, group C （n=41） and group D （n=42） according to random number table. Group A was given Estazolam tablet 1 mg, qd; group B was given Jin＇ s three-needle 30 min/time, qd; group C was given Jiawei wumei pill, one pill, after breakfast and supper warm taking; group D was given Jin＇s three-needle combined with Jiawei wumei pill with same usage as group C. Four groups were treated for 4 weeks. PSQI score, modified Kupperman score, life quality score, serum levels of E2 and FSH were observed in 4 groups before and after treatment, and the occurrence of ADR was recorded. RESULTS： Before treatment, there was no statistical significance in above score （P〉0.05）. After treatment, PSQI score and modified Kupperman score of 4 groups were decreased significantly, compared to before treatment; the group B, C, D were significantly lower than the group A; the group D was significantly lower the group B, C, with statistical significance （P〈0.05）. The life quality score of 4 groups were increased significantly, and the group B, C, D were significantly higher than the group A; the group D was significantly higher than the group B, C, with statistical significance （P〈0.05）. E2 level of group B, C, D were significantly increased, while FSH level was decreased significantly, the improvement of group D was significantly better than group B, C; the improvement of group D was significantly better than that of group B, C, with statistical significance （P〈0.05）. The incidence of ADR in group A was significantly higher than group B, C, D, with statistical significance （P〈0.01）, and there was no statistical significance in the incidence of ADR among group B, C, D, with statistical significance （P〉0.05）. CONCLUSIONS： Jin＇s three needle combined with Jiawei wumei pill is effective in the treatment of perimenopausal insomnia with good safety.