脐血CD64在新生儿早期败血症中的诊断价值

Value of neutrophil CD64 of umbilical cord blood in early diagnosis of neonatal septicemia

目的探讨中性粒细胞CD64在新生儿早期败血症中的临床诊断价值。方法选取2015年6~11月于深圳市龙华新区中心医院产科产检并分娩的50例新生儿,分为感染组(n=18)和对照组(n=32),检测两组出生时脐静脉血、0~12 h外周静脉血CD64水平和血培养,并通过分析两组相同或不同时间CD64的变化,探讨其对新生儿早发型败血症的诊断价值。结果感染组脐静脉血CD64水平高于对照组,差异有统计学意义(t=-3.15,P=0.010);感染组0~12 h外周血CD64较对照组升高,差异有统计学意义(t=-3.35,P=0.004);感染组脐血与0~12 h外周静脉血之间CD64比较,差异无统计学意义(t=-0.507,P=0.623)。结论中性粒细胞CD64对新生儿败血症的早期诊断具有一定的临床应用价值,脐血中性粒细胞CD64可作为宫内细菌感染、早发型败血症的诊断指标。

Objective To explore the clinical significance of neutrophil CD64 in early diagnosis and evaluation of disease condition of neonatal septicemia. Methods This case-control study included 18 neonates with suspected septicemia （septicemia group） and 32 neonates without infection （non-infection group） in our hospital from June 2015 to November 2015. The umbilical venous blood at birth and peripheral venous blood at 0-12 b were collected from all the cases for blood culture and detection of CD64 level. The septicemia group was given recheck of CD64 at 48- 72 h, and the non-infection group was given recheck of CD64 at 72 h, and the levels of CD64 were compared. Results The CD64 levels of both umbilical venous blood and peripheral blood in the septicemia group were significantly higher than those in the non-infection group （t = -3.15 and -3.35, P = 0.010 and 0.004）. However, the CD64 level of umbilical venous blood had no significant change from that of peripheral blood at 0-12 h in the septicemia group （t = -0.507, P = 0.623）. Conclusions Neutrophil CD64 has certain clinical application value in early diagnosis of neonatal septicemia. Neutrophil CD64 of umbilical cord blood can be used as a credible marker for the diagnosis of intrauterine bacterial infection and early onset of septicemia.