左乙拉西坦治疗小儿癫痫的临床疗效和安全性分析

Analysis on Clinical Effect and Safety of Levetiracetam in the Treatment of Children with Epilepsy

目的观察分析左乙拉西坦治疗小儿癫痫的临床疗效和安全性。方法选取我院2014年1月至2016年1月收治的癫痫患儿200例,随机分为观察组和对照组各100例。对照组给予丙戊酸钠治疗,观察组给予左乙拉西坦治疗。观察两组患儿的治疗效果及不良反应发生情况。结果观察组患儿的临床治疗总有效率为95.0%,显著高于对照组的77.0%,差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用左乙拉西坦治疗小儿癫痫,有利于缓解患儿的临床症状,提高治疗总有效率,不良反应发生率低,安全可靠。

Objective To observe and analyze the clinical effect and safety oflevetiracetam in the treatment of children with epilepsy. Methods 200 cases of children with epilepsy admitted to our hospital fi＇om January 2014 to January 2016 were selected and randomly divided into observation group and control group, with 100 cases in each group. The control group was treated with sodium valproate, while the observation group was treated with levetiracetam. The treatment effect and adverse reactions of two groups were observed. Results The total effective rate of observation group was 95.0%, significantly higher than 77.0% of control group, with statistical difference （P〈0.05）. No statistical difference was found in the incidence of adverse reactions between two groups （P 〉0.05）. Conclusions Levetiracetam in the treatment of children with epilepsy is beneficial to alleviate clinical symptoms and improve total effective rate of treatment, with low incidence of adverse reactions, which is safe and reliable.