妊娠糖尿病患者糖化血红蛋白、C-反应蛋白、IL-6与胰岛素抵抗的相关性探讨

Relationship among Glycosylated Hemoglobin,C-Reactive Protein,IL-6 and Insulin Resistance in Patients with Gestational Diabetes Mellitus

目的探讨妊娠糖尿病(GDM)患者糖化血红蛋白、C-反应蛋白、IL-6与胰岛素抵抗的相关性。方法选取40例妊娠期糖尿病患者作为GDM组,30例健康孕妇作为对照组,分别检测其血空腹胰岛素、糖化血红蛋白、C-反应蛋白、IL-6水平,计算胰岛素抵抗指数,并进行相关性统计分析。结果 GDM组的糖化血红蛋白、C-反应蛋白、IL-6含量水平均显著高于对照组,差异有统计学意义(P<0.05)。相关性统计分析显示,胰岛素抵抗指数与糖化血红蛋白、C-反应蛋白、IL-6水平呈正相关。结论妊娠期糖尿病患者的胰岛素抵抗指数与糖化血红蛋白、C-反应蛋白、IL-6有一定的相关性。

Objective To explore the relationship among glycosylated hemoglobin, C-reactive protein, IL-6 and insulin resistance in patients with gestational diabetes mellitus （GDM）. Methods 40 cases of patients with gestational diabetes mellitus were selected as GDM group, and another 30 healthy pregnant women were selected as control group. The levels of fasting insulin, glycosylated hemoglobin, C-reactive protein and IL-6 were detected and the insulin resistance index was calculated, then the correlation was statistically analyzed. Results The levels of glycosylated hemoglobin, C-reactive protein and IL-6 of GDM group were all significantly higher than those of control group, with statistical differences （P 〈0.05）. The statistical correlation analysis showed that the insulin resistance index was positively relative with the levels of glycosylated hemoglobin, C-reactive protein and IL-6. Conclusions The insulin resistance index of patients with gestational diabetes mellitus has a certain relation with glycosylated hemoglobin, C-reactive protein and IL-6.