纳米级有序介孔氧化硅空心球的制备及药物缓释效果

Synthesis and Drug Releasing Effectiveness of Hollow Mesoporous Silica Nanospheres with Ordered Mesochannels

提出一种条件温和、工艺简单的"常温水溶法"制备纳米级有序介孔氧化硅空心球,研究了该空心球作为药物伊利替康(CPT–11)的载体的载药和缓释性能。结果表明:"常温水溶法"能够制备出球形形貌规整、粒径均匀(460 nm)、高比表面积(1 237 m^2/g)且具有有序介孔孔道结构(2.7 nm)的介孔氧化硅空心球,该空心球在药物传输领域具有良好的性能,CPT–11的载药率为14.50%,在pH为7.2、5.5和4.2的环境中108 h药物的释药率分别达28.49%、39.22%和77.72%,该方法适合产业化应用,制备出的纳米级介孔氧化硅空心球有望作为CPT–11药物载体在抗肿瘤领域中得到应用。

The mesoporous silica solid spheres with different silica condensation degrees inside and outside were prepared via the hydrolysis and condensation of tetraethoxysilane （TEOS）. The inner part of solid spheres is more easily dissolved rather than the outer part, and the inner part of the solid spheres is dissolved in deionized water at room temperature to obtain the hollow mesoporous silica nanospheres （HMSS） with ordered mesochannels. A facile method for preparing HMSS by water dissoving at room temperature was developed. The performance of HMSS in drug loading and releasing was investigated. The results show that this method can synthesize the HMSS with a well-defined spherical morphology, uniform particle size （i.e., 460 nm）, high specific surface area （i.e., 1 237 m2/g） and ordered mesochannels （i.e., 2.7 nm）, and the superior performance in drug releasing. The loading content of CPT-11 is 14.50%, and the drug releasing amount in 108 h at pH 7.2, 5.5 and 4.2 can reach 28.49%, 39.22% and 77.72%, respectively.