慢性充血性心力衰竭与电解质紊乱

Chronic congestive heart failure and electrolyte disturbances

电解质广泛分布于细胞内外,参与体内许多重要的功能和代谢活动,对维持正常生命活动起着非常重要的作用。慢性充血性心力衰竭患者由于神经体液的异常激活、进食减少及利尿剂、血管紧张素转化酶抑制剂(ACEI)/血管紧张素Ⅱ受体阻滞剂(ARB)等的应用,常合并多种电解质紊乱。研究表明电解质紊乱可加重心力衰竭患者病情,增加全因死亡、心血管病死亡以及再入院风险,故探讨心力衰竭合并电解质紊乱的机制、并发症及治疗对心力衰竭患者意义重大。

Electrolytes are widely distributed inside and outside of cells,involved in many important functions and metabolic activities and play an important role in biological activities.Because of the neurohumoral abnormalities,less food intake,application of diuretics and ACEI/ARB,the patients with chronic congestive heart failure have always electrolyte disturbances.Studies have shown that electrolyte disturbances could result in disease aggravation,death and re-admissions.Therefore,it is very important to investigate the mechanism,complication and treatment of heart failure complicated with electrolyte disorder.