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肝星状细胞活化、增殖的免疫调控机制研究 被引量:2

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摘要 肝星状细胞(hepatic stellate cells,HSCs)的活化和增殖是肝纤维化发生的中心环节,HSCs活化后可大量合成细胞外基质(extracellular matrix,ECM),在肝组织内异常沉积,从而引起肝纤维化。免疫调控细胞分泌的各种免疫调控因子以及其他活化分子在HSCs活化、增殖中起到重要调控作用。本文就HSCs活化、增殖的免疫调控机制做一综述。
出处 《临床荟萃》 CAS 2017年第3期272-276,共5页 Clinical Focus
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  • 1H. Q.Sun,J. Y.Zhang,H.Zhang,Z. S.Zou,F. S.Wang,J. H.Jia.Increased Th17 cells contribute to disease progression in patients with HBV‐associated liver cirrhosis[J]. Journal of Viral Hepatitis . 2012 (6)
  • 2Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology2008; 134: 1655-1669 [PMID: 18471545 DOI:10.1053/j.gastro.2008.03.003].
  • 3Holt AP, Salmon M, Buckley CD, Adams DH. Immuneinteractions in hepatic fibrosis. Clin Liver Dis 2008; 12: 861-862, x[PMID: 18984471 DOI: 10.1016/j.cld.2008.07.002].
  • 4Marra F, Aleffi S, Galastri S, Provenzano A. Mononuclear cellsin liver fibrosis. Semin Immunopathol 2009; 31: 345-358 [PMID:19533130 DOI: 10.1007/s00281-009-0169-0].
  • 5Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol2008; 214: 199-210 [PMID: 18161745 DOI: 10.1002/path.2277].
  • 6Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. PivotalAdvance: Th-1 cytokines inhibit, and Th-2 cytokines promotefibrocyte differentiation. J Leukoc Biol 2008; 83: 1323-1333 [PMID:18332234 DOI: 10.1189/jlb.1107782].
  • 7Crews FT, Bechara R, Brown LA, Guidot DM, Mandrekar P, OakS, Qin L, Szabo G, Wheeler M, Zou J. Cytokines and alcohol.Alcohol Clin Exp Res 2006; 30: 720-730 [PMID: 16573591 DOI:10.1111/j.1530-0277.2006.00084.x].
  • 8Burke ML, Jones MK, Gobert GN, Li YS, Ellis MK, McManusDP. Immunopathogenesis of human schistosomiasis. ParasiteImmunol 2009; 31: 163-176 [PMID: 19292768 DOI: 10.1111/j.1365-3024.2009.01098.x].
  • 9Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W.Transforming growth factor (TGF)-beta1-producing regulatory Tcells induce Smad-mediated interleukin 10 secretion that facilitatescoordinated immunoregulatory activity and amelioration of TGFbeta1-mediated fibrosis. J Exp Med 2003; 198: 1179-1188 [PMID:14557415 DOI: 10.1084/jem.20030917].
  • 10Muhanna N, Horani A, Doron S, Safadi R. Lymphocyte-hepaticstellate cell proximity suggests a direct interaction. Clin ExpImmunol 2007; 148: 338-347 [PMID: 17437422 DOI: 10.1111/j.1365-2249.2007.03353.x].

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