眼表酸烧伤不同浓度玻璃酸钠治疗效果的研究

Research on the efficacy of different concentrations of sodium hyaluronate for the treatments of ocular surface acid burns

目的观察在治疗眼表酸烧伤过程中，不同浓度的玻璃酸钠滴眼液的治疗效果。方法回顾性分析Ⅰ-Ⅱ度眼表酸烧伤82例（90只眼）的临床资料。病例随机分为两组：第1组，49只眼，以0．1％玻璃酸钠滴眼液滴眼；第2组，41只眼，以0．3％玻璃酸钠滴眼液滴眼。统计治疗后泪膜破裂时间和角膜上皮修复时间。结果两组泪膜破裂时间分别为（3．1±1．8）s，和（5．4±1．9）s；角膜上皮修复时间分别为（4．0±1．6）d和（2．6±1．2）d，两组间的差异均有统计学意义（P=0．001）。结论较高浓度（0．3％）玻璃酸钠滴眼液滴眼能够更好地促进角膜上皮的修复。

Objective To observe the efficacy of different concentrations of sodium hyaluronate for the treatments of ocular surface acid burns. Methods The records of 90 eyes of 82 patients, which suffered from Ⅰ-Ⅱ degree ocular acid burn were analyzed restrospectively. All cases treated with different concentrations of sodium hyaluronate eye drops and were divided into two groups randomly. The concentration of sodium hyaluronate was 0.1% in group A （49 eyes） and 0. 3% in group B （41 eyes）. And the tear film break up time and repair time of corneal epithelium were compared between two groups. Results The tear film break up time after surgery was （3.1 ± 1.8 ） s in group A and （5.4 ± 1.9） s in group B. The repair time of corneal epithelium in group A and group B were （4.0 ± 1.6 ） d and （ 2.6 ± 1.2 ） d respectively. The difference in the corneal epithelium repair time and tear film break up time were statistically significant（ P = 0. 001 ）. Conclusion High concentrations of sodium hyaluronate eye drops （0.3%） are better than the low concentration of the same eyedrop in promoting cornea and conjunctiva repair.