表乳糖的合成研究

Efficient Synthesis of Epilactose

表乳糖又名依匹乳糖,作为一种还原性双糖具有良好的益生效果.以D-甘露糖、D-半乳糖为起始原料,通过合成不同的供体与受体进行偶联筛选,确定了一条表乳糖合成的最佳路线.其总收率达到50%,适宜表乳糖的大量制备.中间体及最终产物的结构均通过NMR、HRMS进行表征.

Epilactose （4-O-β-D-galactopyranosyl-D-mannose） is a reducing disaccharide with satisfactory prebiotic properties. A superior synthetic methods were confirmed by screening different coupled donors and acceptors which were synthesized from D-mannose and D-galactose, respectively. This route gets 50% overall yields and all the intermediates are easily to be purified, making the route suitable for large scale preparation of the target compound. All the compounds were characterized by NMR and HRMS spectra.