肿瘤标志物及生化指标的联合检测对胸腔积液病因的诊断研究

Study on the Diagnosis of Pleural Effusion by Combined Detection of Tumor Markers and Biochemical Parameters

目的探究肿瘤标志物及生化指标的联合检测对胸腔积液病因的诊断价值。方法将41例恶性胸腔积液视为恶性组,41例良性胸腔积液者视为良性组,实施肿瘤标志物及生化指标的联合检测,比较相关结果。结果除ADA指标外,恶性组TP,LDH,CEA,CA199,CA125各指标,与良性组相比,差异均具有统计学意义(P<0.05)。联合法在检测恶性胸腔积液敏感性,特异性和准确性均高于单一检测,差异均具有统计学意义(P<0.05)。结论对于胸腔积液者,实施肿瘤标志物及生化指标的联合检测法,可在短时间内明确病因,方便后续治疗方案制定。

Objective To explore the combined detection of tumor markers and biochemical indicators of pleural effusion etiology diagnosis value. Methods 41 cases of malignant pleural effusion as a group, as a benign group 41 cases of benign pleural effusion, joint detection, tumor markers and biochemical indicators of more relevant results. Results In addition to the ADA index, the malignant group TP, LDH, CEA, CA199, CA125 index, compared with the benign group, the difference was statistically significant（P〈0.05）. The sensitivity, specificity and accuracy of the combined method in detecting malignant pleural effusion were higher than single detection, the difference was statistically significant（P〈0.05）. Conclusion For patients with pleural effusion, combined detection of tumor markers and biochemical markers, in a short period of time to identify the cause of the disease, facilitate the development of follow-up treatment plan.