摘要
目的探究组蛋白去乙酰化酶在恶性肿瘤治疗中的效果。方法选取我院肿瘤科于2015年1—12月收治的80例恶性肿瘤患者作为观察样本,采用平行随机抽样法将其分为对照组与观察组,每组各40例。对照组给予常规化学药物治疗,观察组在常规化疗的基础上给予丙戊酸钠(valproic acid,VPA)治疗,对比两组的近期疗效以及毒副反应情况。结果观察组中CR 7例、PR 11例、NC 14例、PD 8例,总有效率为45%,疾病控制率为80%,均高于对照组,差异具有统计学意义(P<0.05)。结论组蛋白去乙酰化酶在恶性肿瘤治疗中的临床效果确切,可在临床中推广应用。
Objective To investigate the effect of histone deacetylase in the treatment of malignant tumors. Methods 80 cases of malignant tumor were selected in Department of oncology in our hospital from January to December 2015 as the observation sample, using parallel randomly divided into control group and observation group, 40 cases in each group. the control group was given conventional chemotherapy, the observation group on the basis of conventional chemotherapy given valproate（valproic acid, VPA） treatment, curative effect of two groups were compared and the toxicity of the situation. Results In the observation group, CR 7 cases, PR 11 cases, NC 14 cases, PD 8 cases, the total effective rate was 45%, the disease control rate was 80%, significantly higher than the control group, with statistical significance（P〈0.05）. Conclusion The clinical effect of histone deacetylase in the treatment of malignant tumors is accurate, and can be widely used in clinical practice.
作者
孟伟
MENG Wei(Institute of Genetic Engineering, School of Basic Medical Sciences of Southern Medical University, Guangzhou Guangdong 510515, China)
出处
《中国继续医学教育》
2017年第3期142-143,共2页
China Continuing Medical Education
