二甲双胍与炔雌醇环丙孕酮治疗多囊卵巢不孕症效果

The Effect of Metformin and Propargyl Estradiol on Infertility in Polycystic Ovary

目的探讨二甲双胍与炔雌醇环丙孕酮联合应用对多囊卵巢综合征不孕症患者激素水平和妊娠率的影响。方法选取我院收治的96例患者作为研究对象,并将其均分为常规组和联合组。常规组采用常规疗法,联合组采用二甲双胍联合炔雌醇环丙孕酮疗法。对比激素水平变化和妊娠率。结果治疗后,联合组FSH、LH、LH/FSH、空腹胰岛素以及睾酮水平与常规组比较,差异均具有统计学意义(P<0.05);联合组促排卵成功率和妊娠率分别为87.50%和56.25%,均高于常规组的70.83%和33.33%(P<0.05)。结论对多囊卵巢综合征不孕症患者实施二甲双胍联合炔雌醇环丙孕酮治疗不仅能够调节体内激素水平,还可显著提高妊娠率。

Objective To investigate the effect of metformin combined with propargyl estradiol and progesterone on polycystic ovary syndrome hormone level in patients with infertility and pregnancy rate. Methods 96 patients in our hospital were selected as the research object and were divided into two groups. The conventional group were treated with conventional therapy, and the combination group were treated with metformin combined with estradiol estradiol and progesterone therapy. The hormone levels and the pregnancy rates were compared. Results After treatment, the levels of FSH, LH, LH/FSH, fasting insulin and testosterone in the combination group were significantly different from those in the conventional group（P〈0.05）. The success rate and pregnancy rate of the combined group were 87.50% and 56.25% respectively, which were much higher than those of 70.83% and 33.33% of the conventional group（P〈0.05）. Conclusion The application of metformin combined with propargyl estradiol and progesterone in patients can not only regulate hormone levels, but also significantly improve the pregnancy rate.