小鼠体外寄生虫的药浴治疗

Medicated bath for eradication of external parasites in mice

目的伊维菌素全群药浴法治疗小鼠体外寄生虫。方法近800只自繁自用基因工程保种小鼠,伊维菌素药浴液浓度为1%(L/L),每只鼠至少药浴游泳1 min,中途用漏勺把鼠头按压入药液3~4次。10日龄内小鼠需单独人工辅助药浴。药浴后换笼,同时环境驱虫,只药浴1次。结果全群死亡率约2%。随访18个月,未再见到体外寄生虫,鼠群健康,繁殖正常。结论伊维菌素注射液全群药浴法治疗小鼠体外寄生虫切实可行。

Objective To report the results of medicated bath with ivermectin for eradication of external parasites in mice. Methods Nearly 800 genetically engineered mice which are self-used were treated with ivermectin medicated bath in concentration of 1% （L/L） to eradicate external parasites. Each mouse swims at least 1 minute, including immersing the head into solution for 3 - 4 times with a colander. Manual auxiliary medicated bath was needed for less than 10-day ones. All cages and materials were changed after the medicated bath, and environmental disinfection was performed at the same time. Medicated bath was used only once. Results Mortality rate of the mice was about 2%. The mice were followed-up for 18 months, and no reinfection with external parasites was observed. The mice were healthy and reproduction was normal. Conclusions Medicated bath with ivermectin is effective and feasible for eradication of external parasites in laboratory mice.