宫颈癌患者血清中hmga1和CK19蛋白的表达及其临床意义

Expression of Serum Levels of hmga1 and CK19 Protein in Cervical Cancer and Clinical Significance

目的检测宫颈癌患者血清中高迁移率蛋白A1(hmga1)和细胞角蛋白(CK)19的表达并分析其临床意义。方法 37例宫颈癌患者为实验组,同期体检健康者50例为对照组;采用酶联免疫吸附法(Elisa)检测两组血清中hmga1和CK19蛋白水平;分析hmga1和CK19蛋白水平与宫颈癌临床病理特征的关系;记录2年随访复发患者例数,比较复发患者与未复发患者的血清hmga1和CK19蛋白水平。结果与对照组比较,宫颈癌组血清hmga1和CK19蛋白水平明显升高(P<0.01);血清hmga1和CK19蛋白水平与宫颈癌患者年龄、病理类型无明显相关性(P>0.05),而与宫颈癌患者的FIGO分期、分化程度及淋巴结转移呈显著相关(P<0.01);复发患者入院时血清hmga1和CK19蛋白水平明显高于未复发者,比较差异有统计学意义(P<0.01)。结论宫颈癌患者血清hmga1和CK19蛋白水平明显升高,与宫颈癌的恶性程度密切相关,对该病的临床预后评估具有临床价值。

Objective To investigate the expression of serum levels of hmga 1 and CK19 in cervical cancer and clinical significance.Methods 37 cases with cervical cancer were the experimental group .50 healthy cases was the control group .Elisa method was empolyed to detect serum levels of hmga 1 and CK19 of the 2 groups.Serum levels of hmga1 and CK19 and its correla-tion with clinicopathological parameters of age ,gender,pathology,differentiation,TNM grades,and lymphatic metastasis were ana-lyzed.2-year follow-up was conducted to all cases ,recurrent cases,and serum levels of hmga1 and CK19 in recurrent group and non-recurrent cases were compared .Results Serum levels of hmga1 and CK19 were obviously higher than the control group （P〈0.01）.Serum levels of hmga1 and CK19 had no significant correlation with age and pathological type （P〉0.05）,and had signifi-cant correlation with differentiation,FIGO stage,and lymph node metastasis,there had statistical difference （P〈0.01）.Serum levels of hmga1 and CK19 in recurrent group were higher than non-recurrent group,there had statistical differenc（P〈0.01）. Conclusion Serum levels of hmga1 and CK19 of cervical cancer obviously increased ,which is closely related with grade malig-nancy ,and could be clinical value in evaluating prognosis .