血清免疫球蛋白、红细胞免疫及外周血T淋巴细胞亚群检验对治疗小儿肺炎支原体感染的指导意义

The significance of the detection of serum immunoglobulin,erythrocyte immunity and T lymphocyte subsets in the treatment of children with Mycoplasma pneumoniae infection

目的:探讨血清免疫球蛋白、红细胞免疫及外周血T淋巴细胞亚群检验对治疗小儿肺炎支原体感染的指导意义。方法:将肺炎支原体感染的患儿198例作为观察组,选择同期入院体检的健康儿童180例作为对照组,检测两组儿童血清免疫球蛋白、红细胞免疫及外周血T淋巴细胞亚群的水平并进行比较。结果:两组儿童IgG、IgA、CD8^+和CD4^+/CD8^+指标比较差异不大(P>0.05),观察组患儿IgM、免疫粘附抑制分子水平高于对照组(P<0.05),C_(3b)受体花环率、红细胞免疫复合物花环率、免疫粘附促进因子、CD4^+、CD3^+水平低于对照组(P<0.05)。结论:小儿肺炎支原体感染后会引起免疫功能降低,临床治疗过程中适度调节免疫功能对改善病情可能起到积极的作用。

Objective：To study the significance of the detection of serum immunoglobulin, erythrocyte immunity and T lymphocyte subsets in the treatment of children with Mycoplasma pneumoniae infection. Methods： 198 cases of children with Mycoplasma pneumoniae infection were se- lected as the observation group, and 180 healthy children were selected as the control group at the same period. The levels of serum immunoglobu- lin, erythrocyte immune function and peripheral blood T lymphocyte subsets were compared between the two groups. Results： There was no significant difference between the two groups in the level of IgG,IgA ,CD8 ＋ and CD4 ＋/CD8 ＋ （ P 〉 0.05 ）. In the observation group, the levels of IgM and immune adherence inhibition were significantly higher than those in the control group. The rosette rate of C3b receptor ceil and Erythrocyte immunity complex, and the level of mmune adherence enhance factor, CD4＋and CD8＋ were significantly lower than that in the control group （ P 〈 0.05 ）. Conclusion ： Immune function of children with Mycoplasma pneumoniae infection will decrease. In the course of clinical treatment, moderate regulation of immune function plays a positive role in improving the condition of the disease.