新序贯疗法对幽门螺杆菌阳性消化性溃疡的治疗效果

Evaluation of treatment effect of new sequential therapy on helicobacter pylori positive peptic ulcer

目的:探讨新序贯疗法对幽门螺杆菌阳性消化性溃疡的临床治疗效果。方法:选取幽门螺杆菌阳性消化性溃疡患者94例作为研究对象,将其随机分为观察组和对照组,各47例。观察组患者予以兰索拉唑、阿莫西林、甲硝唑、克拉霉素4种药物新序贯疗法,对照组患者予以兰索拉唑、阿莫西林、克拉霉素3种药物三联疗法,观察两组患者的相关临床指标变化情况。结果:观察组患者的幽门螺杆菌根除率(91.49%)优于对照组患者的幽门螺杆菌根除率(72.34%),差异具有统计学意义(P<0.05)。结论:对幽门螺杆菌阳性消化性溃疡患者予以新序贯疗法具有较好的治疗效果,能够最大程度根除幽门螺杆菌,值得在临床中应用推广。

Objective ：To probe into the clinical treatment effect of new sequential therapy on helicobacter pylori positive peptic ulcer. Methods： 94 cases of helicobacter pylori positive peptic ulcer were chosen and randomly divided into the observation group and the control group, with 47 cases in each group. The observation group was treated by new sequential therapy which consists of lansoprazole, amoxicillin, metronidazole, clarithromycin while the control group was treated by triple therapy which consists of lansoprazole, amoxicillin, clarithmmyein, the changes of clini- cal indicators of the two groups observed. Results：The eradication rate of Helicobacter pylori in the observation group （91.49 % ） was higher than that in the control group （72.34 % ）, the difference between which being statistically significant （ P 〈 0.05 ）. Conclusion：The treatment effect of new sequential therapy on helicobacter pylori positive peptic ulcer is good enough to eradicate the helicohacter pylori to a large extent, which is worth promoting clinically.