胆固醇酯转运蛋白-629C/A基因多态性与脑梗死的关系

Relationship between polymorphism of cholesteryl ester transfer protein-629C/A gene and cerebral infarction

目的:从基因角度研究脑梗死发病的影响因素。方法:选择脑梗死患者200例(对照组)和健康体检者170例(对照组),用聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术检测基因型。结果:观察组CETP-629C/A位点的A等位基因频率以及突变纯合子AA基因型频率高于对照组(P<0.05),CETP-629C/A位点AC、CC组间的基因型频率,C等位基因频率两组间比较差异无统计学意义(P>0.05);AA基因型、低密度脂蛋白、胆固醇、甘油三酯为脑梗死独立危险因素(OR>1,P<0.05)。结论:CETP-629C/A基因位点AA基因型是脑梗死发病的危险因素。

Objective： To study the relationship between polymorphism of cholesteryl ester transfer protein（CETP） - 629C/A gene and cerebral infarction, Methods：A total of 200 eases of patients with cerebral infarction, and 170 cases of healthy objects checked up in physical examination received polymerase chain reaction restriction fragment length polymorphism （PCR -RELP） genotype detection technology. Results：The CETP- 629C/A site of cerebral infarction group A allele frequency and mutation homozygote AA genotype frequency was significantly higher than that of the control group （ P 〈0.05）, and CETP- 629C/A ganotype AC, CC groups, and C allele frequencies between the two groups had no statistical difference （ P 〉 0.05 ）. AA genotype, low - density lipoprotein, cholesterol, and triglyeerides were independent risk factors for cerebral infarction （ OR 〉 1, P 〈0.05）. Conclusion：CETP -629C/A gene AA genotype was the risk factor for cerebral infarction.